ZNF488

Gene Information

Official Symbol: ZNF488
Official Name: zinc finger protein 488
Aliases and Previous Symbols: N/A
Entrez ID: 118738
UniProt: Q96MN9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Temozolomide 200μM R04 exp189	-2.09
JQ1 0.01μM R03 exp130	-2.08
UMK57 1μM R01 exp59	-2.04
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.01
Chloramphenicol 2μM R00 exp12	-1.95
Nocodazole 0.02μM R00 exp23	-1.93
Pimelic-diphenylamide-106 5μM R00 exp28	-1.78

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16393
Expression level (log2 read counts): -0.67

Expression Distribution

positive regulation of myelination
positive regulation of oligodendrocyte differentiation
regulation of oligodendrocyte differentiation
positive regulation of glial cell differentiation
oligodendrocyte development
regulation of myelination
positive regulation of nervous system process
positive regulation of gliogenesis
oligodendrocyte differentiation
regulation of glial cell differentiation
glial cell development
regulation of gliogenesis
regulation of nervous system process
glial cell differentiation
gliogenesis
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
regulation of system process
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
negative regulation of biosynthetic process
neurogenesis
cell development
negative regulation of gene expression
positive regulation of multicellular organismal process