ZRSR2

Official Symbol: ZRSR2
Official Name: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Aliases and Previous Symbols: N/A
Entrez ID: 8233
UniProt: Q15696
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008].
UniProt Summary: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vincristine 0.0005μM R04 exp190	-2.53
UM0011500 5μM R05 exp245	-2.35
BML-284 0.09μM R08 exp460	-2.22
CCT251545 0.2μM R06 exp271	-2.13
Etoposide 0.1μM R05 exp198	-2.1
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.99
IU1-C 25μM R04 exp183	-1.97
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-1.96
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.95
MK-1775 0.32μM R02 exp75	-1.94
BN82002 4μM R07 exp340	-1.91
Momordin-Ic 10μM R08 exp506	-1.9
Selumetinib 20μM R02 exp81	-1.89
BAY-598 4μM R05 exp220	-1.89
Vinorelbine 0.001μM R05 exp249	-1.89
Apcin 50 to 100μM on day4 R04 exp176	-1.85
Ethanol 0.003 R08 exp437	-1.8
2-Deoxy-D-glucose 800μM R05 exp214	-1.79
Heregulin-B 44ng/ml R08 exp486	-1.79
Apcin 25μM plus proTAME 2μM R04 exp177	-1.73
3-Bromopyruvate 7μM R04 exp175	-1.71
Vitamin-D3 40μM R08 exp536	1.79
PU-H71 1μM R08 exp515	2.02
42°C R08 exp539	2.05
Salinomycin 3.5μM R08 exp521	2.08
BVD-523 15μM R02 exp67	2.32
Vemurafenib 6.6μM R08 exp434	2.41
BI-6727 0.04μM R03 exp98	2.49

Global Fraction of Cell Lines Where Essential: 612/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	26/26
bone	24/26
breast	23/30
central nervous system	40/49
cervix	4/4
colorectal	17/17
esophagus	11/11
fibroblast	1/1
gastric	11/14
kidney	11/18
liver	16/19
lung	67/72
lymphocyte	15/16
ovary	20/25
pancreas	19/22
peripheral nervous system	11/15
plasma cell	7/12
prostate	1/1
skin	19/20
soft tissue	7/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	26/28
uterus	4/5

Expression Distribution

U2AF
pre-mRNA 3-splice site binding
U12-type spliceosomal complex
spliceosomal complex assembly
spliceosomal complex
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression