ZRSR2 [The Human Chemical-Genetic Interaction Map Project]

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======= ZRSR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZRSR2
  * **<color #00a2e8>Official Name</color>**: zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8233|8233]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15696|Q15696]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZRSR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZRSR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2AF|
|pre-mRNA 3-splice site binding|
|U12-type spliceosomal complex|
|spliceosomal complex assembly|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.53|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.35|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.22|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.13|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.1|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.99|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.97|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.96|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.95|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.94|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-1.91|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.9|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.89|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.89|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.89|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.85|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.8|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.79|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.79|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.73|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.71|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.02|
|[[:results:exp539|42°C R08 exp539]]|2.05|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.08|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.32|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.41|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.586|
|[[:human genes:v:vezt|VEZT]]|0.56|
|[[:human genes:a:atxn10|ATXN10]]|0.554|
|[[:human genes:g:gemin8|GEMIN8]]|0.551|
|[[:human genes:p:pmm2|PMM2]]|0.545|
|[[:human genes:r:rpp21|RPP21]]|0.539|
|[[:human genes:d:dpagt1|DPAGT1]]|0.536|
|[[:human genes:t:triap1|TRIAP1]]|0.527|
|[[:human genes:z:zcrb1|ZCRB1]]|0.521|
|[[:human genes:a:adsl|ADSL]]|0.519|
|[[:human genes:r:rtcb|RTCB]]|0.513|
|[[:human genes:a:atp5b|ATP5B]]|0.507|
|[[:human genes:a:alg1|ALG1]]|0.503|
|[[:human genes:g:gemin6|GEMIN6]]|0.501|
|[[:human genes:s:slc25a26|SLC25A26]]|0.5|
|[[:human genes:e:elac2|ELAC2]]|0.497|
|[[:human genes:y:yars|YARS]]|0.497|
|[[:human genes:p:ppcs|PPCS]]|0.497|
|[[:human genes:g:gemin7|GEMIN7]]|0.488|
|[[:human genes:u:uhrf1|UHRF1]]|0.488|
|[[:human genes:r:rpia|RPIA]]|0.48|
|[[:human genes:g:gmppb|GMPPB]]|0.479|
|[[:human genes:p:ppa2|PPA2]]|0.478|
|[[:human genes:c:cep57|CEP57]]|0.478|
|[[:human genes:n:naf1|NAF1]]|0.476|
|[[:human genes:r:rnmt|RNMT]]|0.475|
|[[:human genes:f:fh|FH]]|0.474|
|[[:human genes:t:ttc4|TTC4]]|0.474|
|[[:human genes:d:ddx20|DDX20]]|0.472|
|[[:human genes:r:rpe|RPE]]|0.471|
|[[:human genes:p:ppp4c|PPP4C]]|0.468|
|[[:human genes:a:atp5o|ATP5O]]|0.468|
|[[:human genes:l:lsm10|LSM10]]|0.466|
|[[:human genes:t:trmt5|TRMT5]]|0.466|
|[[:human genes:e:eif1ax|EIF1AX]]|0.464|
|[[:human genes:p:ppp6c|PPP6C]]|0.462|
|[[:human genes:g:gfpt1|GFPT1]]|0.461|
|[[:human genes:d:dhps|DHPS]]|0.461|
|[[:human genes:d:dohh|DOHH]]|0.457|
|[[:human genes:t:ten1|TEN1]]|0.455|
|[[:human genes:m:mrps11|MRPS11]]|0.455|
|[[:human genes:t:timm22|TIMM22]]|0.454|
|[[:human genes:t:tamm41|TAMM41]]|0.454|
|[[:human genes:e:exoc4|EXOC4]]|0.45|
|[[:human genes:c:cct7|CCT7]]|0.448|
|[[:human genes:a:atic|ATIC]]|0.447|
|[[:human genes:c:c15orf41|C15orf41]]|0.447|
|[[:human genes:c:cox16|COX16]]|0.446|
|[[:human genes:t:tti1|TTI1]]|0.446|
|[[:human genes:d:dhrsx|DHRSX]]|0.445|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.444|
|[[:human genes:r:rad1|RAD1]]|0.443|
|[[:human genes:m:med16|MED16]]|0.443|
|[[:human genes:r:rabggtb|RABGGTB]]|0.439|
|[[:human genes:r:rft1|RFT1]]|0.436|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.436|
|[[:human genes:m:mrps14|MRPS14]]|0.432|
|[[:human genes:u:utp23|UTP23]]|0.432|
|[[:human genes:c:ctc1|CTC1]]|0.432|
|[[:human genes:s:snapc5|SNAPC5]]|0.431|
|[[:human genes:s:srp14|SRP14]]|0.43|
|[[:human genes:t:tbca|TBCA]]|0.43|
|[[:human genes:p:ppcdc|PPCDC]]|0.43|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.428|
|[[:human genes:t:tomm22|TOMM22]]|0.428|
|[[:human genes:r:rfk|RFK]]|0.428|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.428|
|[[:human genes:r:rptor|RPTOR]]|0.427|
|[[:human genes:t:tbcb|TBCB]]|0.425|
|[[:human genes:g:gemin5|GEMIN5]]|0.425|
|[[:human genes:d:dolk|DOLK]]|0.423|
|[[:human genes:a:alg14|ALG14]]|0.422|
|[[:human genes:g:gatc|GATC]]|0.422|
|[[:human genes:m:mrps16|MRPS16]]|0.421|
|[[:human genes:n:nae1|NAE1]]|0.42|
|[[:human genes:t:tmem41b|TMEM41B]]|0.42|
|[[:human genes:n:nars|NARS]]|0.42|
|[[:human genes:a:atp5j|ATP5J]]|0.419|
|[[:human genes:s:slc25a19|SLC25A19]]|0.419|
|[[:human genes:m:msto1|MSTO1]]|0.418|
|[[:human genes:b:bap1|BAP1]]|0.418|
|[[:human genes:n:nsmce1|NSMCE1]]|0.417|
|[[:human genes:m:mrpl27|MRPL27]]|0.415|
|[[:human genes:f:fnta|FNTA]]|0.414|
|[[:human genes:t:tsen54|TSEN54]]|0.414|
|[[:human genes:n:nbn|NBN]]|0.414|
|[[:human genes:h:hspd1|HSPD1]]|0.413|
|[[:human genes:d:dars2|DARS2]]|0.413|
|[[:human genes:r:rpusd4|RPUSD4]]|0.412|
|[[:human genes:e:elp3|ELP3]]|0.412|
|[[:human genes:t:txnl4b|TXNL4B]]|0.412|
|[[:human genes:t:tprkb|TPRKB]]|0.412|
|[[:human genes:t:tmem242|TMEM242]]|0.411|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.411|
|[[:human genes:a:alg2|ALG2]]|0.41|
|[[:human genes:a:alg13|ALG13]]|0.41|
|[[:human genes:t:taf1a|TAF1A]]|0.41|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.408|
|[[:human genes:u:uap1|UAP1]]|0.406|
|[[:human genes:g:gnb1l|GNB1L]]|0.406|
|[[:human genes:t:tpk1|TPK1]]|0.406|
|[[:human genes:m:mrpl21|MRPL21]]|0.405|
|[[:human genes:z:zbtb11|ZBTB11]]|0.405|
|[[:human genes:t:telo2|TELO2]]|0.403|
|[[:human genes:o:oraov1|ORAOV1]]|0.403|
|[[:human genes:p:polr3h|POLR3H]]|0.402|
|[[:human genes:d:dap3|DAP3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 612/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|26/26|
|bone|24/26|
|breast|23/30|
|central nervous system|40/49|
|cervix|4/4|
|colorectal|17/17|
|esophagus|11/11|
|fibroblast|1/1|
|gastric|11/14|
|kidney|11/18|
|liver|16/19|
|lung|67/72|
|lymphocyte|15/16|
|ovary|20/25|
|pancreas|19/22|
|peripheral nervous system|11/15|
|plasma cell|7/12|
|prostate|1/1|
|skin|19/20|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|26/28|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2587
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZRSR2 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>