Selumetinib 20μM R02 exp81
Mechanism of Action
Inhibits MEK1 and MEK2
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: Selumetinib
- Synonyms: AZD6244; ARRY-142886
- CAS #: 606143-52-6
- PubChem CID: 10127622
- IUPAC: 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
- INCHI Name: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
- INCHI Key: CYOHGALHFOKKQC-UHFFFAOYSA-N
- Molecular Weight: 457.7
- Canonical SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
- Isomeric SMILES: N/A
- Molecular Formula: C17H15BrClFN4O3
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S1008
- Lot #: S100831
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H15BrClFN4O3 457.00729; found 457.00736
Dose Response Curve
- Platform ID: AZD6244
- Min: -13.1322; Max: 7.7239
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 02
- Dose: 20µM
- Days of incubation: 8
- Doublings: 6.3
- Numbers of reads: 11566448
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 6/3 | Scores |
Selumetinib 20μM R02 exp81
