ING1

Entrez Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.63
Actinomycin-D 0.001μM R00 exp3	-2.46
Hippuristanol 0.12μM R08 exp488	-2.34
RK-33 8μM R08 exp518	-2.21
TRAIL 50ng/ml R00 exp36	-2.19
BML-284 0.09μM R08 exp460	-2.12
5-Fluorouracil 20μM R00 exp2	-2.08
Selumetinib 20μM R02 exp81	-2.05
Rotenone 20μM R00 exp34	-2.03
Taxol 0.004μM R03 exp103	-2.02
Wortmannin 5μM R00 exp38	-2
Talazoparib 0.006μM R06 exp299	-1.92
BI-D1870 3.15μM R02 exp66	-1.9
Trametinib 10μM R02 exp83	-1.83
BI-D1870 2μM R04 exp162	-1.75
Bleomycin 5μM R08 exp459	-1.73
Bortezomib 0.05μM R00 exp7	-1.72
Methotrexate 0.01μM R08 exp501	1.72
Chloramphenicol 20μM R00 exp13	1.81
RO-3307 4.7μM R02 exp80	1.83
NMS-873 0.07μM R07 exp380	1.97
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.04
CR131-b 0.005μM R08 exp474	2.05
Betulinic acid 10 to 15μM on day4 R05 exp222	2.06
Doxycycline 10μM R00 exp18	2.07
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.14
THZ531 0.11μM R07 exp409	2.17
Oligomycin-A 2μM R00 exp25	2.23
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.33
ML-792 0.2μM R08 exp505	2.55
THZ531 0.225μM R08 exp444	2.59
THZ531 0.11 to 0.175μM on day4 R07 exp413	3.05
LY2090314 0.003μM R08 exp499	3.3
LY2090314 0.003μM R08 exp500 no dilution day6	3.38
Lead acetate 2000μM R08 exp498 no dilution day6	4.16
Lead acetate 2000μM R08 exp497	4.24

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PHD
ING

methylated histone binding
negative regulation of cell growth
negative regulation of growth
regulation of cell growth
regulation of growth
negative regulation of cell population proliferation
cell cycle
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process