SUDS3

Entrez Summary: N/A
UniProt Summary: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sin3-type complex
Sin3 complex
histone deacetylase activity
substantia nigra development
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
neural nucleus development
midbrain development
histone deacetylase binding
protein deubiquitination
nuclear body
protein modification by small protein removal
enzyme binding
histone modification
covalent chromatin modification
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
chromatin organization
brain development
head development
negative regulation of transcription by RNA polymerase II
apoptotic process
central nervous system development
protein modification by small protein conjugation or removal
programmed cell death
chromosome organization
cell death
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
proteolysis
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
regulation of apoptotic process