Wiskostatin 3μM R07 exp422

Mechanism of Action

Inhibits N-WASP, blocks actin polymerization

  • Class / Subclass 1: Organelle Function / Cytoskeletal Inhibitor
  • Class / Subclass 2: Cell Cycle / Actin Inhibitor

Technical Notes

Compound References

  • PubChem Name: Wiskostatin
  • Synonyms: N/A
  • CAS #: 253449-04-6
  • PubChem CID: 2775510
  • IUPAC: 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol
  • INCHI Name: InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
  • INCHI Key: XUBJEDZHBUPBKL-UHFFFAOYSA-N
  • Molecular Weight: 426.1
  • Canonical SMILES: CN(C)CC(CN1C2=C(C=C(C=C2)Br)C3=C1C=CC(=C3)Br)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C17H18Br2N2O

Compound Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: W498925
  • Lot #: 7-MWC-89-1

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H18Br2N2O 424.98587; found 424.98566

Dose Response Curve

  • Platform ID: Wiskostatin
  • Min: -1.6934; Max: 99.8632





IC Concentration (µM)
IC10 N/A
IC20 2.2422
IC30 2.8245
IC40 3.4258
IC50 4.0977
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 3µM
  • Days of incubation: 8
  • Doublings: 6.5
  • Numbers of reads: 18623672

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
7/1ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1