DTYMK
Gene Information
- Official Symbol: DTYMK
- Official Name: deoxythymidylate kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 1841
- UniProt: P23919
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the conversion of dTMP to dTDP.
Pfam Domains GO Terms
Pfam Domains
| Thymidylate kin |
GO Terms
| dTDP biosynthetic process |
| pyrimidine deoxyribonucleoside biosynthetic process |
| pyrimidine deoxyribonucleoside diphosphate metabolic process |
| thymidylate kinase activity |
| pyrimidine nucleoside diphosphate biosynthetic process |
| pyrimidine deoxyribonucleoside diphosphate biosynthetic process |
| dUDP metabolic process |
| dTDP metabolic process |
| dUDP biosynthetic process |
| thymidine biosynthetic process |
| deoxyribonucleoside biosynthetic process |
| pyrimidine nucleoside diphosphate metabolic process |
| uridylate kinase activity |
| dTTP biosynthetic process |
| pyrimidine deoxyribonucleoside triphosphate biosynthetic process |
| deoxyribonucleoside diphosphate biosynthetic process |
| pyrimidine deoxyribonucleoside metabolic process |
| dTTP metabolic process |
| thymidine metabolic process |
| deoxyribonucleoside diphosphate metabolic process |
| deoxyribonucleoside triphosphate biosynthetic process |
| pyrimidine deoxyribonucleoside triphosphate metabolic process |
| deoxyribonucleoside metabolic process |
| pyrimidine deoxyribonucleotide biosynthetic process |
| nucleoside diphosphate biosynthetic process |
| deoxyribose phosphate biosynthetic process |
| 2-deoxyribonucleotide biosynthetic process |
| nucleoside monophosphate phosphorylation |
| deoxyribonucleotide biosynthetic process |
| pyrimidine nucleoside biosynthetic process |
| deoxyribonucleoside triphosphate metabolic process |
| pyrimidine nucleoside triphosphate biosynthetic process |
| nucleoside diphosphate kinase activity |
| pyrimidine deoxyribonucleotide metabolic process |
| pyrimidine nucleoside triphosphate metabolic process |
| nucleobase-containing small molecule interconversion |
| 2-deoxyribonucleotide metabolic process |
| deoxyribose phosphate metabolic process |
| myoblast differentiation |
| deoxyribonucleotide metabolic process |
| pyrimidine nucleoside metabolic process |
| nucleoside biosynthetic process |
| glycosyl compound biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| pyrimidine-containing compound biosynthetic process |
| nucleoside diphosphate phosphorylation |
| nucleotide phosphorylation |
| pyrimidine nucleotide metabolic process |
| nucleoside triphosphate biosynthetic process |
| response to cadmium ion |
| nucleoside monophosphate metabolic process |
| response to estrogen |
| mitochondrial intermembrane space |
| nucleoside diphosphate metabolic process |
| nucleoside triphosphate metabolic process |
| pyrimidine-containing compound metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| glycosyl compound metabolic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| mitochondrial matrix |
| response to metal ion |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| muscle structure development |
| cellular response to growth factor stimulus |
| response to growth factor |
| response to inorganic substance |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| organophosphate metabolic process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| JQ1 0.8μM R08 exp435 | -2.29 |
| AICAR 240μM R05 exp211 | -2.2 |
| A-395 10μM R05 exp218 | -2.19 |
| Wiskostatin 3μM R07 exp422 | -2.02 |
| Centrinone 0.5μM R07 exp343 | -2.01 |
| R-DABN 8μM R03 exp111 | -2.01 |
| Doxycycline 10μM R00 exp18 | -1.94 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | -1.8 |
| Demecolcine 0.03μM R05 exp228 | -1.76 |
| Nifuroxazide 5μM R03 exp102 | -1.76 |
| Clomiphene 4.4μM R02 exp68 | -1.74 |
| Trientine 500μM R08 exp534 | -1.7 |
| Curcumin 6.5μM R06 exp277 | 1.72 |
| Glyphosate 1000μM R06 exp283 | 2.27 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 683/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 21/26 |
| breast | 32/33 |
| central nervous system | 43/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 20/21 |
| liver | 16/20 |
| lung | 70/75 |
| lymphocyte | 16/16 |
| ovary | 21/26 |
| pancreas | 23/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 8/9 |
| thyroid | 1/2 |
| upper aerodigestive | 21/22 |
| urinary tract | 26/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 36
- Expression level (log2 read counts): 5.77
Expression Distribution
DTYMK Expression in NALM6 Cells: 5.77
