Curcumin 6.5μM R06 exp277
Mechanism of Action
Component of tumeric spice, many claimed activities but viewed as pan-assay interference compound
- Class / Subclass 1: Uncharacterized Mechanism / Natural Product
- Class / Subclass 2: Metabolism / Nutraceutical
Technical Notes
Compound References
- PubChem Name: Curcumin
- Synonyms: Turmeric yellow; Natural Yellow 3; Diferuloylmethane
- CAS #: 458-37-7
- PubChem CID: 969516
- IUPAC: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
- INCHI Name: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
- INCHI Key: VFLDPWHFBUODDF-FCXRPNKRSA-N
- Molecular Weight: 368.4
- Canonical SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
- Isomeric SMILES: COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
- Molecular Formula: IC21H20O6
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: 238384
- Lot #: CW2318MW
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H20O6 369.13326; found 369.13368
Dose Response Curve
- Platform ID: Curcumin
- Min: -8.9938; Max: 98.5043
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 9.9199 |
| IC30 | 10.6220 |
| IC40 | 11.2344 |
| IC50 | 11.8275 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 06
- Dose: 6.5µM
- Days of incubation: 8
- Doublings: 6.4
- Numbers of reads: 8501108
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Curcumin 6.5μM R06 exp277
