ID4
Gene Information
- Official Symbol: ID4
- Official Name: inhibitor of DNA binding 4, HLH protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 3400
- UniProt: P47928
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| seminal vesicle morphogenesis |
| prostate gland stromal morphogenesis |
| seminal vesicle development |
| negative regulation of astrocyte differentiation |
| negative regulation of oligodendrocyte differentiation |
| central nervous system myelination |
| axon ensheathment in central nervous system |
| prostate gland epithelium morphogenesis |
| prostate gland morphogenesis |
| cerebral cortex neuron differentiation |
| negative regulation of glial cell differentiation |
| regulation of astrocyte differentiation |
| neuroblast proliferation |
| regulation of oligodendrocyte differentiation |
| negative regulation of gliogenesis |
| prostate gland development |
| oligodendrocyte development |
| negative regulation of fat cell differentiation |
| stem cell proliferation |
| negative regulation of DNA binding |
| RNA polymerase II transcription factor binding |
| oligodendrocyte differentiation |
| regulation of glial cell differentiation |
| neural precursor cell proliferation |
| hippocampus development |
| gland morphogenesis |
| fat cell differentiation |
| myelination |
| glial cell development |
| axon ensheathment |
| ensheathment of neurons |
| limbic system development |
| regulation of gliogenesis |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| regulation of fat cell differentiation |
| regulation of DNA binding |
| osteoblast differentiation |
| circadian rhythm |
| protein dimerization activity |
| negative regulation of binding |
| glial cell differentiation |
| pallium development |
| central nervous system neuron differentiation |
| gliogenesis |
| connective tissue development |
| negative regulation of neuron differentiation |
| transcription corepressor activity |
| telencephalon development |
| ossification |
| mitotic cell cycle phase transition |
| rhythmic process |
| cell cycle phase transition |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| urogenital system development |
| transcription factor binding |
| negative regulation of cell development |
| regulation of binding |
| forebrain development |
| gland development |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| cell population proliferation |
| tissue morphogenesis |
| mitotic cell cycle process |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| mitotic cell cycle |
| negative regulation of cell differentiation |
| brain development |
| head development |
| regulation of neurogenesis |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| central nervous system development |
| cell cycle process |
| neuron differentiation |
| epithelium development |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12968
- Expression level (log2 read counts): 4.46
Expression Distribution
ID4 Expression in NALM6 Cells: 4.46
