ID4 [The Human Chemical-Genetic Interaction Map Project]

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======= ID4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ID4
  * **<color #00a2e8>Official Name</color>**: inhibitor of DNA binding 4, HLH protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3400|3400]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47928|P47928]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ID4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ID4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600581|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|seminal vesicle morphogenesis|
|prostate gland stromal morphogenesis|
|seminal vesicle development|
|negative regulation of astrocyte differentiation|
|negative regulation of oligodendrocyte differentiation|
|central nervous system myelination|
|axon ensheathment in central nervous system|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|cerebral cortex neuron differentiation|
|negative regulation of glial cell differentiation|
|regulation of astrocyte differentiation|
|neuroblast proliferation|
|regulation of oligodendrocyte differentiation|
|negative regulation of gliogenesis|
|prostate gland development|
|oligodendrocyte development|
|negative regulation of fat cell differentiation|
|stem cell proliferation|
|negative regulation of DNA binding|
|RNA polymerase II transcription factor binding|
|oligodendrocyte differentiation|
|regulation of glial cell differentiation|
|neural precursor cell proliferation|
|hippocampus development|
|gland morphogenesis|
|fat cell differentiation|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|limbic system development|
|regulation of gliogenesis|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|regulation of fat cell differentiation|
|regulation of DNA binding|
|osteoblast differentiation|
|circadian rhythm|
|protein dimerization activity|
|negative regulation of binding|
|glial cell differentiation|
|pallium development|
|central nervous system neuron differentiation|
|gliogenesis|
|connective tissue development|
|negative regulation of neuron differentiation|
|transcription corepressor activity|
|telencephalon development|
|ossification|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|urogenital system development|
|transcription factor binding|
|negative regulation of cell development|
|regulation of binding|
|forebrain development|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|cell population proliferation|
|tissue morphogenesis|
|mitotic cell cycle process|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|central nervous system development|
|cell cycle process|
|neuron differentiation|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.76|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.79|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.86|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.88|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.1|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.13|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.14|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|2.2|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.25|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.33|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.38|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.501|
|[[:human genes:n:nsd1|NSD1]]|0.432|
|[[:human genes:f:fbxo11|FBXO11]]|0.419|
|[[:human genes:r:runx1|RUNX1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12968
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ID4 Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>