CAY10603 0.55μM R08 exp467

Inhibits HDAC6, selective over other HDACs

PubChem Name: HDAC6 Inhibitor
Synonyms: BML-281
CAS #: 1045792-66-2
PubChem CID: 24951314
IUPAC: tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
INCHI Name: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
INCHI Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
Molecular Weight: 446.5
Canonical SMILES: CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO
Isomeric SMILES: N/A
Molecular Formula: C22H30N4O6

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
8/0	Scores	View	View	View	View	View

Screen	Correlation	Plot
CB-839 10μM R05 exp224	0.073	View
Wortmannin 5μM R00 exp38	0.07	View
EPZ-5676 30μM R05 exp233	0.068	View
Ibrutinib 10μM R08 exp442	0.065	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.065	View
Cannabidiol 20μM R08 exp466	0.063	View
Wiskostatin 3μM R07 exp422	0.062	View
IU1-47 25μM R04 exp182	0.061	View
Quercetin 20μM R08 exp517	0.059	View
Wortmannin 0.5μM R00 exp37	0.054	View
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	0.052	View
FK-506 5μM R07 exp358	0.052	View
SB203580 25μM R03 exp149	0.052	View
GSK626616 14μM R08 exp485	0.051	View
Thapsigargin 0.005μM R07 exp407	0.051	View
B02 10μM R08 exp453	0.054	View