TUBGCP4

Gene Information
  • Official Symbol: TUBGCP4
  • Official Name: tubulin gamma complex associated protein 4
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 27229
  • UniProt: Q9UGJ1
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
  • UniProt Summary: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 1619
  • Expression level (log2 read counts): 7.07

Expression Distribution

  • Last modified: 2025/12/10 20:19
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