TUBGCP4 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBGCP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBGCP4
  * **<color #00a2e8>Official Name</color>**: tubulin gamma complex associated protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27229|27229]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGJ1|Q9UGJ1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBGCP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBGCP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc97 Spc98|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|equatorial microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|microtubule nucleation by microtubule organizing center|
|gamma-tubulin ring complex|
|microtubule minus-end binding|
|gamma-tubulin complex|
|microtubule nucleation|
|gamma-tubulin binding|
|microtubule polymerization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule organization|
|protein polymerization|
|spindle assembly|
|structural constituent of cytoskeleton|
|recycling endosome|
|spindle pole|
|microtubule cytoskeleton|
|spindle organization|
|meiotic cell cycle|
|microtubule|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.91|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.72|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.8|
|[[:results:exp303|39°C R06 exp303]]|1.83|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 374/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|13/28|
|bone|14/26|
|breast|16/33|
|central nervous system|27/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|10/21|
|liver|10/20|
|lung|47/75|
|lymphocyte|9/16|
|ovary|12/26|
|pancreas|16/24|
|peripheral nervous system|9/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|9/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBGCP4 Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>