Wortmannin 0.5μM R00 exp37

Mechanism of Action

Inhibits PI3K and PI3K-related enzymes, non-specific covalent inhibitor

  • Class / Subclass 1: Signal Transduction / Kinase Inhibitor
  • Class / Subclass 2: Proteostasis / Autophagy Inhibitor

Technical Notes

Compound References

  • PubChem Name: Wortmannin
  • Synonyms: SL-2052; KY-12420
  • CAS #: 19545-26-7
  • PubChem CID: 312145
  • IUPAC: [(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate
  • INCHI Name: InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
  • INCHI Key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
  • Molecular Weight: 428.4
  • Canonical SMILES: CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
  • Isomeric SMILES: CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
  • Molecular Formula: DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG

Compound Supplier

  • Supplier Name: LC Laboratories
  • Catalog #: W-2990
  • Lot #: SS-107

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C23H24O8 451.13634; found 451.1358

Dose Response Curve

  • Platform ID: Wortmannin
  • Min: -10.7381; Max: 63.3011





IC Concentration (µM)
IC10 N/A
IC20 1.6783
IC30 3.4255
IC40 6.1479
IC50 10.5153
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 00
  • Dose: 500nM
  • Days of incubation: 8
  • Doublings: 5.7
  • Numbers of reads: 9470449

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
6/3ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1