KIF11

Entrez Summary: This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). {ECO:0000269|PubMed:19001501, ECO:0000269|PubMed:23857769}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.39
Arsenate 40μM R06 exp264	-2.34
Olaparib 4μM R08 exp512	-2.25
Thimerosal 0.85μM R08 exp529	-2.06
BI-6727 0.0125μM R03 exp97	-2.02
UM131593 0.2μM R03 exp106	-2.02
Dinaciclib 0.007μM R07 exp355	-2.01
JQ1 0.8μM R08 exp435	-2
2-Methoxyestradiol 0.55μM R07 exp310	-1.98
Rapamycin 2μM R07 exp306	-1.86
Torin1 0.08μM R02 exp82	-1.84
Senexin-A 25μM R07 exp400	-1.83
Thapsigargin 0.005μM R07 exp407	-1.81
VE-822 0.04μM R06 exp300	-1.78
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.74
Actinomycin-D 0.01μM R00 exp4	-1.74
CCCP 0.1μM R00 exp10	1.7
Metformin 40μM R03 exp132	1.72
CCCP 1μM R00 exp11	1.75
CCT251545 20μM R07 exp326	1.77
UM0011500 10μM R05 exp246	1.77
SGC2096 2.6μM R03 exp153	1.78
A-196 10μM R03 exp114	1.85
GSK2606414 1μM R05 exp236	1.89
RO-3306 3 to 4μM on day4 R04 exp165	1.9
UMK57 0.6μM R03 exp107	1.94
A-366 10μM R03 exp115	1.96
GSK-LSD1 10μM R03 exp123	1.98
D-Fructose 10000μM R06 exp279	2.01
Tozasertib 0.1μM R07 exp414	2.09
LJH685 5μM R02 exp73	2.19
Oligomycin-A 2μM R00 exp25	2.26
Nocodazole 0.02μM R00 exp23	2.7
Chloramphenicol 20μM R00 exp13	2.73
Cycloheximide 0.02μM R00 exp14	2.76
Bortezomib 0.005μM R00 exp6	2.85
Wortmannin 0.5μM R00 exp37	3
Cycloheximide 0.2μM R00 exp15	3.05
Doxycycline 10μM R00 exp18	3.11
Pimelic-diphenylamide-106 0.5μM R00 exp27	3.3
Betulinic acid 10 to 15μM on day4 R05 exp222	3.45
5-Fluorouracil 2μM R00 exp1	3.69

Global Fraction of Cell Lines Where Essential: 737/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

Gene	Correlation
SYT9	0.407
POLR2J3	0.403

mitotic centrosome separation
centrosome separation
regulation of mitotic centrosome separation
ATP-dependent microtubule motor activity, plus-end-directed
spindle microtubule
mitotic spindle assembly
kinesin complex
regulation of centrosome cycle
microtubule motor activity
mitotic spindle organization
mitotic spindle
centrosome cycle
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
microtubule organizing center organization
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
spindle assembly
microtubule cytoskeleton organization involved in mitosis
spindle
spindle pole
mitotic nuclear division
spindle organization
regulation of mitotic nuclear division
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
regulation of microtubule cytoskeleton organization
antigen processing and presentation of peptide antigen
regulation of nuclear division
antigen processing and presentation
regulation of microtubule-based process
ATPase activity
microtubule binding
microtubule-based movement
nuclear division
organelle fission
microtubule
Golgi vesicle transport
protein kinase binding
microtubule cytoskeleton organization