A-196 10μM R03 exp114
Mechanism of Action
Inhibits SUV420H1 and SUV420H2 inhibitor, blocks di/trimethylation of H4K20me
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
- Synonyms: N/A
- CAS #: 1982372-88-2
- PubChem CID: 117072548
- IUPAC: 6,7-dichloro-N-cyclopentyl-4-pyridin-4-ylphthalazin-1-amine
- INCHI Name: InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24)
- INCHI Key: ABGOSOMRWSYAOB-UHFFFAOYSA-N
- Molecular Weight: 359.2
- Canonical SMILES: C1CCC(C1)NC2=NN=C(C3=CC(=C(C=C32)Cl)Cl)C4=CC=NC=C4
- Isomeric SMILES: N/A
- Molecular Formula: C18H16Cl2N4
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H16Cl2N4 359.08248; found 359.08319
Dose Response Curve
- Platform ID: A-196
- Min: 0.0245; Max: 32.4348
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 11.6475 |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 10µM
- Days of incubation: 8
- Doublings: 7.5
- Numbers of reads: 10046263
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 4/0 | Scores |
A-196 10μM R03 exp114
A-196 10μM R03 exp114 vs SB203580 25μM R03 exp149
