KIAA0020

Entrez Summary: N/A
UniProt Summary: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress (PubMed:21266351). Binds to double-stranded RNA or DNA without sequence specificity (PubMed:25512524). Involved in development of the eye and of primordial germ cells (By similarity). {ECO:0000250|UniProtKB:X1WGX5, ECO:0000269|PubMed:21266351, ECO:0000269|PubMed:25512524}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thimerosal 0.85μM R08 exp529	-2.31
A-196 10μM R03 exp114	-2.27
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.19
iCRT14 30μM R08 exp492	-1.93
Nutlin-3A 1.6μM R06 exp294	-1.83
Cannabidiol 20μM R08 exp466	-1.76
Cryptotanshinone 12μM R05 exp227	-1.71
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	2
BI-2536 0.0042μM R03 exp95	2.01
THZ531 0.225μM R08 exp444	2.49
ML-792 0.2μM R08 exp505	3.61

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of protein ADP-ribosylation
chromosome
nucleolus
endoplasmic reticulum
RNA binding
DNA binding
regulation of protein modification process