Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
Mechanism of Action
Inhibits microtubule polymerization
- Class / Subclass 1: Cell Cycle / Microtubule Poison
- Class / Subclass 2: Organelle Function / Cytoskeletal Inhibitor
Technical Notes
Compound References
- PubChem Name: Combretastatin A4
- Synonyms: CRC 87-09
- CAS #: 117048-59-6
- PubChem CID: 5351344
- IUPAC: 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
- INCHI Name: InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
- INCHI Key: HVXBOLULGPECHP-WAYWQWQTSA-N
- Molecular Weight: 316.3
- Canonical SMILES: COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
- Isomeric SMILES: COC1=C(C=C(C=C1)/C=C\\C2=CC(=C(C(=C2)OC)OC)OC)O
- Molecular Formula: C18H20O5
Compound Supplier
- Supplier Name: Abcam
- Catalog #: AB120925
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H20O5 317.13835; found 317.13863
Dose Response Curve
- Platform ID: Combretastatin_A4
- Min: -2.6499; Max: 88.5172
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0017 |
| IC30 | 0.0019 |
| IC40 | 0.0022 |
| IC50 | 0.0024 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 04
- Dose: 0.002-0.003µM
- Days of incubation: 8
- Doublings: 5.7
- Numbers of reads: 23260964
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 23/5 | Scores |
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Demecolcine 0.03μM R05 exp228
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs S-trityl-L-cysteine 0.5μM R05 exp243
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Vincristine 0.0005μM R04 exp190
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Ixabepilone 0.004 to 0.005μM on day4 R04 exp184
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Mdivi-1 15μM R05 exp217
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs UMK57 1μM R01 exp59
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Quercetin 20μM R08 exp517
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs UMK57 0.6μM R03 exp107
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Vinblastine 0.002μM R01 exp60
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Taxol 0.004μM R03 exp103
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs HMS-I1 1μM R01 exp46
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Sulforaphane 9μM R08 exp526 no dilution day6
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Sulforaphane 9μM R08 exp525
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Epothilone-B 0.0015μM R05 exp231
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs LY2090314 0.003μM R08 exp500 no dilution day6
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs GSK461364A 0.005μM R03 exp125
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs UM131593 0.2μM R03 exp106
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Docosahexaenoic-acid 50μM R07 exp356
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Rifampicin 10μM R00 exp32
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs GSK626616 14μM R08 exp485
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179 vs Genistein 15μM R07 exp360
Colchicine 0.009μM R05 exp215 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
BML-284 0.09μM R08 exp460 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
2-Methoxyestradiol 0.55μM R07 exp310 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
BI-D1870 2μM R04 exp162 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
Cabazitaxel 0.001μM R05 exp223 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
BI-6727 0.0125μM R03 exp97 vs Combretastatin A4 0.002 to 0.003μM day4 R04 exp179
