ANP32A

Entrez Summary: N/A
UniProt Summary: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. {ECO:0000269|PubMed:10400610, ECO:0000269|PubMed:11360199, ECO:0000269|PubMed:15642345, ECO:0000269|PubMed:17557114}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-2.53
UMK57 1μM R01 exp59	-2.41
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.32
BI-6727 0.04μM R03 exp98	-2.26
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	-2.09
Oligomycin-A 20μM R00 exp26	-2.03
BML-284 0.09μM R08 exp460	-1.94
MSC2530818 10μM R07 exp379	-1.89
42°C R08 exp539	-1.88
Mdivi-1 15μM R05 exp217	-1.8
Dynasore 10μM R04 exp180	-1.79
TRAIL 5ng/ml R00 exp35	-1.79
Vinblastine 0.002μM R01 exp60	-1.77
BI-2536 0.02μM R03 exp96	-1.75
Quercetin 20μM R08 exp517	-1.73
LY2090314 0.003μM R08 exp500 no dilution day6	1.83
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.96
Rapamycin 0.001μM R08 exp429	2.02
Nicotine 3000μM R08 exp510	2.07
Arsenic trioxide 60μM R08 exp449	2.08
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.1
CHIR-124 0.04μM R06 exp272	2.18
EPZ-5676 30μM R05 exp233	2.24
GSK626616 14μM R08 exp485	2.37
Rapamycin 2μM R07 exp306	2.43
Ethanol 0.01 R05 exp234	2.51
Rapamycin 10μM R00 exp30	2.52
Erlotinib 10μM R05 exp216	2.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
nucleocytoplasmic transport
nuclear transport
regulation of mRNA metabolic process
posttranscriptional regulation of gene expression
perinuclear region of cytoplasm
regulation of cellular catabolic process
regulation of catabolic process
endoplasmic reticulum
RNA binding
intracellular transport
intracellular signal transduction
establishment of localization in cell