PTMA

Entrez Summary: N/A
UniProt Summary: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-2.46
BVD-523 15μM R02 exp67	-2.07
Colchicine 0.009μM R05 exp215	-2.05
SB743921 0.001μM R05 exp244	-1.88
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.7
THZ531 0.225μM R08 exp444	1.7
Chloramphenicol 20μM R00 exp13	1.77
Citral 50μM R06 exp274	1.79
Thimerosal 0.85μM R08 exp529	1.8
IU1-C 25μM R04 exp183	1.81
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.83
Latrunculin-B 10μM R07 exp374	1.85
5-Azacytidine 2μM R07 exp330	1.86
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.86
Cryptotanshinone 12μM R05 exp227	1.87
Trichostatin-A 0.06μM R07 exp415	1.87
QNZ 0.01μM R05 exp241	1.88
Trientine 500μM R08 exp534	1.96
Mubritinib 0.2μM R01 exp48	1.97
Tunicamycin 0.04μM R07 exp418	1.97
Oligomycin-A 2μM R00 exp25	2.05
All-trans-Retinoic-Acid 40μM R07 exp334	2.07
MLN-4924 0.2μM R00 exp21	2.11
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.14
MS023 2μM R03 exp134	2.25
UM0129480 7μM R02 exp85	2.25
Amiloride 100μM R08 exp447	2.28
NMS-873 0.07μM R07 exp380	2.41
Tozasertib 0.1μM R07 exp414	2.62
Docosahexaenoic-acid 50μM R07 exp356	2.82
TRAIL 5ng/ml R00 exp35	2.98
Mubritinib 0.2μM R02 exp65	3.3
Doxycycline 10μM R00 exp18	3.31
GSK626616 14μM R08 exp485	3.41
Bortezomib 0.005μM R00 exp6	3.98
Ethanol 0.01 R05 exp234	4.14
TRAIL 50ng/ml R00 exp36	4.17

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activating transcription factor binding
histone exchange
ATP-dependent chromatin remodeling
histone binding
nucleosome organization
chromatin remodeling
protein-DNA complex subunit organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
chromatin organization
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
chromosome organization
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
regulation of apoptotic process
regulation of programmed cell death
cellular nitrogen compound biosynthetic process
RNA metabolic process
regulation of cell death
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression