All-trans-Retinoic-Acid 40μM R07 exp334

Mechanism of Action

Ligand for retinoic acid receptor (RAR) and retinoid X receptor (RXR), metabolite of vitamin A1

  • Class / Subclass 1: Gene Regulation / Nuclear Receptor Ligand
  • Class / Subclass 2: Metabolism / Metabolite

Technical Notes

Compound References

  • PubChem Name: Tretinoin
  • Synonyms: ATRA; Tretinoin; Vitamin A acid; all-trans-Retinoic acid; ATRA;Tretinoin;Vitamin A acid;all-trans-Retinoic acid
  • CAS #: 302-79-4
  • PubChem CID: 444795
  • IUPAC: (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
  • INCHI Name: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
  • INCHI Key: SHGAZHPCJJPHSC-YCNIQYBTSA-N
  • Molecular Weight: 300.4
  • Canonical SMILES: CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
  • Isomeric SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C
  • Molecular Formula: C20H28O2

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: R2625
  • Lot #: SLBB5473V

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H28O2 301.21621; found 301.21722

Dose Response Curve

  • Platform ID: ATRA
  • Min: 8.9864; Max: 98.8174





IC Concentration (µM)
IC10 N/A
IC20 0.0445
IC30 0.8254
IC40 6.3558
IC50 36.2335
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 40µM
  • Days of incubation: 8
  • Doublings: 1.8
  • Numbers of reads: 23385042

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
6/9ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1