SP2

Entrez Summary: N/A
UniProt Summary: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.71
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.19
THZ531 0.11μM R07 exp409	-2.16
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.88
Bisphenol S 100μM R08 exp458	-1.83
Diepoxybutane 3μM R07 exp354	-1.74
Ethanol 0.01 R05 exp234	1.78
BS-181 20μM R08 exp461	1.82
Trametinib 10μM R02 exp83	1.9
Rotenone 20μM R00 exp34	1.91
Lead acetate 2000μM R08 exp498 no dilution day6	1.94
Tunicamycin 0.04μM R07 exp418	2.18
All-trans-Retinoic-Acid 40μM R07 exp334	2.28
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.39
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.61
2-Deoxy-D-glucose 800μM R05 exp214	3.03
Thapsigargin 0.005μM R07 exp407	3.6

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

multicellular organism growth
histone deacetylase binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
developmental growth
growth
RNA polymerase II proximal promoter sequence-specific DNA binding
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression
immune response