2-Deoxy-D-glucose 800μM R05 exp214

Inhibits phosphoglucoisomerase, competitive, blocks glycolysis

PubChem Name: Deoxyglucose
Synonyms: 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
CAS #: 154-17-6
PubChem CID: 108223
IUPAC: (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
INCHI Name: InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
INCHI Key: VRYALKFFQXWPIH-PBXRRBTRSA-N
Molecular Weight: 164.16
Canonical SMILES: C(C=O)C(C(C(CO)O)O)O
Isomeric SMILES: C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
Molecular Formula: C6H12O5

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
10/60	Scores	View	View	View	View	View

Screen	Correlation	Plot
MS023 7μM R03 exp135	0.082	View
MS023 2μM R03 exp134	0.08	View
Ethanol 0.01 R05 exp234	0.067	View
Olaparib 4μM R08 exp512	0.065	View
UM0129480 7μM R02 exp85	0.063	View
Artemisinin 50μM R08 exp450	0.061	View
Milciclib 2μM R08 exp502	0.06	View
6-Thio-2-deoxyguanosine 2μM R06 exp259	0.058	View
Hippuristanol 0.12μM R08 exp488	0.057	View
CB-5083 0.4μM R08 exp468	0.056	View
Cytochalasin-B 5μM R07 exp349	0.055	View
Thapsigargin 0.005μM R07 exp407	0.055	View
Hippuristanol 0.12μM R08 exp489 no dilution day6	0.054	View
ML-792 0.2μM R08 exp505	0.054	View
MLN-4924 0.2μM R00 exp21	0.053	View
SNS-032 15μM R08 exp443	0.053	View
AICAR 240μM R05 exp211	0.051	View
FK-506 30μM R07 exp359	0.051	View

GO Term	Fold Change	Genes
mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)	306.85	ATP5F1B,ATP5F1E
proton-transporting ATP synthase complex, catalytic core F(1)	245.48	ATP5F1B,ATP5F1E
mitochondrial respiratory chain complex assembly	28.22	NDUFB10,TIMM21,NDUFAF1,SCO2
oxidative phosphorylation	24.80	NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E
inner mitochondrial membrane protein complex	23.25	NDUFB10,TIMM21,ATP5F1B,NDUFAF1,ATP5F1E
cellular respiration	18.16	NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E,SCO2
mitochondrial protein-containing complex	15.68	SLC25A5,NDUFB10,TIMM21,ATP5F1B,NDUFAF1,MRPL55,ATP5F1E
mitochondrial inner membrane	13.40	SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,NDUFAF1,MRPL55,ATP5F1E,SCO2
organelle inner membrane	13.24	SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,NDUFAF1,MRPL55,ATP1B4,ATP5F1E,SCO2
energy derivation by oxidation of organic compounds	13.11	NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E,SCO2
mitochondrion organization	11.69	SLC25A5,BCL2L1,NDUFB10,TIMM21,RCC1L,ATG9A,NDUFAF1,SCO2
generation of precursor metabolites and energy	9.79	NDUFB10,ATP5F1B,NDUFAF1,G6PD,ATP5F1E,SCO2
mitochondrial membrane	9.58	SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,ATG9A,NDUFAF1,MRPL55,ATP5F1E,SCO2
mitochondrial matrix	9.06	SLC25A5,BCL2L1,ATP5F1B,NDUFAF1,MRPL55,ATP5F1E,SCO2
mitochondrial envelope	8.99	SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,ATG9A,NDUFAF1,MRPL55,ATP5F1E,SCO2

GO Term	Fold Change	Genes
tRNA wobble position uridine thiolation	368.22	MOCS3,CTU2
tRNA thio-modification	276.17	MOCS3,CTU2
isocitrate metabolic process	220.93	IDH1,ACO2
glucose 6-phosphate metabolic process	82.85	HK2,PGLS,TKT
purine nucleotide metabolic process	9.69	PGLS,IDH1,TKT,HINT1,ATIC,SLC4A7,IMPDH2
nucleotide metabolic process	9.65	PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2
nucleoside phosphate metabolic process	9.46	PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2
purine-containing compound metabolic process	9.05	PGLS,IDH1,TKT,HINT1,ATIC,SLC4A7,IMPDH2
nucleobase-containing small molecule metabolic process	8.24	PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2
organophosphate metabolic process	7.03	PFKP,HK2,PGLS,IDH1,TKT,MOCS3,HINT1,AK6,ATIC,SLC4A7,IMPDH2
carbohydrate derivative metabolic process	5.43	PFKP,HK2,STT3B,PGLS,TKT,HINT1,ATIC,IMPDH2,MAGT1