CHMP7

Entrez Summary: N/A
UniProt Summary: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
FK-506 30μM R07 exp359	-3.19
Rotenone 0.07μM R08 exp431	-2.93
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.71
Latrunculin-B 10μM R07 exp374	-2.53
Bisphenol A 100μM R06 exp269	-2.49
Dynasore 7μM R08 exp436	-2.38
Cannabidiol 20μM R08 exp466	-2.37
Staurosporine 0.02μM R08 exp524	-2.37
2-Deoxy-D-glucose 800μM R05 exp214	-2.31
Pterostilbene 16μM R02 exp78	-2.27
ML-792 0.2μM R08 exp505	-2.21
Centrinone 0.5μM R07 exp343	-2.19
Ibrutinib 10μM R08 exp442	-2.09
Rapamycin 10μM R00 exp30	-2.09
Cerivastatin 0.15μM R05 exp226	-2.05
GSK626616 14μM R08 exp485	-2.03
3-Bromopyruvate 7μM R04 exp175	-1.97
Thapsigargin 0.005μM R07 exp407	-1.95
Dynasore 10μM R04 exp180	-1.92
BI-D1870 3.15μM R02 exp66	-1.85
Senexin-A 25μM R07 exp400	-1.85
Cytochalasin-B 5μM R07 exp349	-1.84
Docosahexaenoic-acid 50μM R07 exp356	-1.82
THZ531 0.11μM R07 exp409	-1.8
Ethanol 0.01 R05 exp234	-1.79
KU-0063794 3.8μM R02 exp71	-1.79
CB-839 10μM R05 exp224	-1.78
Cryptotanshinone 12μM R05 exp227	-1.78
Wiskostatin 3μM R07 exp422	-1.71

Global Fraction of Cell Lines Where Essential: 112/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	5/28
blood	1/28
bone	5/26
breast	9/33
central nervous system	11/56
cervix	1/4
colorectal	3/17
esophagus	1/13
fibroblast	0/1
gastric	3/16
kidney	2/21
liver	4/20
lung	13/75
lymphocyte	0/16
ovary	3/26
pancreas	6/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	1/1
skin	2/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	7/22
urinary tract	5/29
uterus	0/5

Expression Distribution

Snf7
PspA IM30

ESCRT III complex
ESCRT complex disassembly
ESCRT III complex disassembly
exit from mitosis
midbody abscission
late endosome to vacuole transport
nuclear envelope reassembly
mitotic cytokinetic process
viral budding via host ESCRT complex
protein localization to chromatin
viral budding
multivesicular body assembly
multivesicular body organization
cytokinetic process
virion assembly
mitotic metaphase plate congression
nuclear envelope organization
metaphase plate congression
protein localization to chromosome
mitotic cytokinesis
establishment of chromosome localization
chromosome localization
endosome organization
cytoskeleton-dependent cytokinesis
cytokinesis
mitotic sister chromatid segregation
chromatin
nucleus organization
vacuolar transport
sister chromatid segregation
mitotic nuclear division
nuclear envelope
viral life cycle
nuclear chromosome segregation
endosomal transport
protein-containing complex disassembly
mitotic cell cycle phase transition
chromosome segregation
cell cycle phase transition
nuclear division