KU-0063794 3.8μM R02 exp71
Mechanism of Action
ATP-competitive mTORC1 and mTORC2 inhibitor
- Class / Subclass 1: Proteostasis / mTOR inhibitor
- Class / Subclass 2: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: Ku-0063794
- Synonyms: N/A
- CAS #: 938440-64-3
- PubChem CID: 16736978
- IUPAC: [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
- INCHI Name: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
- INCHI Key: RFSMUFRPPYDYRD-CALCHBBNSA-N
- Molecular Weight: 465.5
- Canonical SMILES: CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
- Isomeric SMILES: C[C@@H]1CN(C[C@@H](O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
- Molecular Formula: C25H31N5O4
Compound Supplier
- Supplier Name: Selleck Chemicals
- Catalog #: S1226
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C25H31N5O4 466.24488; found 466.246
Dose Response Curve
- Platform ID: KU-0063794
- Min: -18.4031; Max: 67.0870
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 1.9729 |
| IC30 | 2.9378 |
| IC40 | 4.0717 |
| IC50 | 5.4936 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 02
- Dose: 3.8µM
- Days of incubation: 8
- Doublings: 3.3
- Numbers of reads: 7908560
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 4/3 | Scores |
KU-0063794 3.8μM R02 exp71
KU-0063794 3.8μM R02 exp71 vs Torin1 0.08μM R02 exp82
KU-0063794 3.8μM R02 exp71 vs Rapamycin 1μM R00 exp29
INK128 0.2μM R02 exp70 vs KU-0063794 3.8μM R02 exp71
