QARS
Gene Information
- Official Symbol: QARS1
- Official Name: glutaminyl-tRNA synthetase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5859
- UniProt: P47897
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Glutamine–tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866). {ECO:0000269|PubMed:24656866, ECO:0000269|PubMed:26869582}.
Pfam Domains GO Terms
Pfam Domains
| tRNA synt 1c R2 |
| tRNA-synt 1c C |
| tRNA-synt 1c |
| tRNA synt 1c R1 |
GO Terms
| glutaminyl-tRNA aminoacylation |
| glutamine-tRNA ligase activity |
| aminoacyl-tRNA synthetase multienzyme complex |
| protein kinase inhibitor activity |
| negative regulation of stress-activated MAPK cascade |
| tRNA aminoacylation for protein translation |
| negative regulation of stress-activated protein kinase signaling cascade |
| tRNA aminoacylation |
| amino acid activation |
| negative regulation of MAPK cascade |
| tRNA metabolic process |
| negative regulation of protein kinase activity |
| negative regulation of apoptotic signaling pathway |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| cellular amino acid metabolic process |
| mitochondrial matrix |
| translation |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| peptide biosynthetic process |
| negative regulation of phosphorylation |
| protein kinase binding |
| ncRNA metabolic process |
| negative regulation of intracellular signal transduction |
| amide biosynthetic process |
| peptide metabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| protein-containing complex |
| regulation of cellular response to stress |
| brain development |
| regulation of MAPK cascade |
| head development |
| cellular amide metabolic process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| regulation of transferase activity |
| central nervous system development |
| negative regulation of cell death |
| oxoacid metabolic process |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 719/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 27/28 |
| blood | 27/28 |
| bone | 25/26 |
| breast | 33/33 |
| central nervous system | 55/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 15/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 27/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 443
- Expression level (log2 read counts): 7.96
Expression Distribution
QARS Expression in NALM6 Cells: 7.96
