RNMT

Gene Information

Official Symbol: RNMT
Official Name: RNA guanine-7 methyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 8731
UniProt: O43148
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-2.45
Tubastatin-A 2.5μM R07 exp417	-2.21
ABT-702 0.1μM R06 exp260	-1.99
CHIR-124 0.04μM R06 exp272	-1.97
Etoposide 0.1μM R05 exp198	-1.95
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.92
Nicotinamide Riboside 100μM R03 exp139	-1.9
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.84
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-1.78
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.78
Geldanamycin 0.01μM R05 exp235	-1.77
GSK591 2.6μM R03 exp128	-1.76
Temozolomide 200μM R04 exp189	-1.76
Vemurafenib 6.6μM R08 exp434	-1.76
GSK2606414 1μM R05 exp236	-1.72
Azithromycin 100μM R08 exp452	-1.71
Vinblastine 0.2μM R03 exp108	1.73
MS023 7μM R03 exp135	1.76
Aphidicolin 0.4μM R08 exp440	1.83
Nocodazole 0.2μM R02 exp64	1.83
Bleomycin 5μM R08 exp459	1.85
Ammonium tetrathiomolybdate 10μM R08 exp448	1.86
Salinomycin 3.5μM R08 exp521	1.87
Etoposide 1μM R00 exp19	1.88
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.94
GSK461364A 0.1μM R03 exp126	1.94
Mitomycin-C 0.06μM R08 exp503	2.04
Hinokiflavone 12μM R08 exp487	2.06
Actinomycin-D 0.01μM R00 exp4	2.08
Pimelic-diphenylamide-106 5μM R00 exp28	2.19
5-Fluorouracil 20μM R00 exp2	2.24
Etoposide 0.3μM R05 exp199	2.26
Nocodazole 0.1μM R03 exp94	2.4
THZ1 0.06μM R08 exp531	2.51
Tanespimycin 14μM R08 exp527	2.56
Atovaquone 15μM R08 exp451	2.61
Actinomycin-D 0.001μM R00 exp3	2.64
BI-6727 0.04μM R03 exp98	2.72
BI-2536 0.02μM R03 exp96	3.01
DABN racemic mixture R03 exp93	3.29

Gene	Correlation
THG1L	0.717
RPTOR	0.711
GMPPB	0.703
PMM2	0.674
MED16	0.671
ALG1	0.67
DPAGT1	0.666
HSPD1	0.664
DOHH	0.65
GFPT1	0.646
GTF3C2	0.642
GNB1L	0.64
RTCB	0.628
ORAOV1	0.625
POLR3H	0.621
BAP1	0.621
CSNK2B	0.621
EIF4E	0.611
ALG13	0.608
TRIAP1	0.607
DHPS	0.602
GTF3C4	0.601
NARS	0.601
PELO	0.597
AARS	0.597
CCDC101	0.597
MTOR	0.597
TRNT1	0.593
SRP72	0.593
ALG2	0.591
NAE1	0.591
GTF3C3	0.59
TTI2	0.59
TTI1	0.59
ALG5	0.589
ADSL	0.589
RPP21	0.587
UHRF1	0.577
UAP1	0.577
ATP5J	0.576
WDR24	0.574
SRP68	0.574
HARS	0.573
TSEN54	0.573
ATXN10	0.572
CCT7	0.572
PAM16	0.571
EXOC4	0.57
TGS1	0.569
DAD1	0.568
VEZT	0.568
EPRS	0.565
YARS	0.565
GTF3C6	0.565
CBFB	0.564
MARS	0.563
MEAF6	0.561
SRP14	0.56
OSGEP	0.559
ENY2	0.557
HAUS8	0.553
POLR3B	0.552
DDX20	0.551
UTP23	0.551
UBE2G2	0.55
UXT	0.548
RPN1	0.548
PPP2R3C	0.542
MAPK14	0.538
EXOC3	0.538
DHDDS	0.531
SLC35B1	0.527
MED23	0.526
TELO2	0.525
SEC61G	0.525
TIMM22	0.524
NSD1	0.518
MLLT1	0.517
CASP9	0.517
TIMM13	0.517
CRCP	0.515
ZNF259	0.514
VRK1	0.513
TRMT5	0.513
PLAA	0.511
ZFX	0.511
FAF2	0.511
VMP1	0.51
BUB3	0.509
DDOST	0.509
ALG14	0.509
TMEM41B	0.508
TBCA	0.507
FNTA	0.505
OTUD5	0.505
CDIPT	0.505
PPA2	0.505
ATP5O	0.503
SEH1L	0.502
SPCS2	0.501
TSEN34	0.501
DNAJC3	0.5
TAZ	0.5
TRMT10A	0.499
UBA3	0.498
TTC4	0.496
PHB	0.494
MED4	0.494
HCCS	0.491
GTF2A2	0.489
WARS	0.488
VHL	0.486
DR1	0.486
TAMM41	0.485
CARS	0.485
LSM11	0.485
LSMD1	0.483
NSMCE1	0.483
PPCS	0.482
ATP5B	0.482
GEMIN5	0.481
THOC6	0.48
SHOC2	0.478
LAMTOR5	0.478
CMTR1	0.477
MAD2L1	0.477
TRIM28	0.476
ZRSR2	0.475
WDR59	0.474
APAF1	0.474
TXNRD1	0.473
KDSR	0.472
XPO6	0.472
ELAC2	0.472
PISD	0.472
TXNL4B	0.471
EEF1E1	0.47
SDHA	0.47
BAK1	0.468
FLI1	0.467
ATP2A2	0.466
SNAPC5	0.466
SSBP2	0.465
PPP4C	0.465
GPN2	0.464
SOX7	0.464
CTDNEP1	0.463
SPCS3	0.462
DDX55	0.462
DKC1	0.46
CEP350	0.459
NAF1	0.458
DCTN6	0.458
UBE2K	0.458
GTF3A	0.456
RBM14	0.456
THOC3	0.455
DOLK	0.455
ENO1	0.454
DHX29	0.454
EIF3F	0.453
TBP	0.453
RAD1	0.452
TPRKB	0.452
XPOT	0.451
PIK3R4	0.45
ROMO1	0.449
PDAP1	0.449
HMGB2	0.449
QARS	0.448
LMO2	0.447
TEN1	0.446
WDR82	0.445
GEMIN6	0.445
IRF2BP2	0.444
RPE	0.443
ACTR10	0.443
TMED10	0.442
ALG6	0.442
GEMIN8	0.441
CHCHD4	0.44
OIP5	0.44
DNAJB11	0.439
SSB	0.439
SNF8	0.439
TLE4	0.438
TBCD	0.437
WDR92	0.437
DPF2	0.436
CYCS	0.436
ABCF1	0.435
FGFR1OP	0.434
NUPL2	0.434
MAX	0.433
SLC25A26	0.433
ABCB7	0.432
POLR3C	0.432
PGGT1B	0.432
MAML1	0.432
UBE2J1	0.43
PTCHD3	0.43
ID3	0.429
ASXL2	0.429
UBE2M	0.428
MBTPS2	0.427
ZBTB11	0.424
AGO2	0.424
KIF14	0.423
NXT1	0.423
ATF7IP	0.423
CRLS1	0.422
LAMTOR4	0.422
DCTN5	0.42
DICER1	0.42
SRPRB	0.42
CHORDC1	0.42
ATP5H	0.419
ERCC2	0.416
UBE2L3	0.415
GTF2H3	0.415
DERL2	0.414
PSMG4	0.414
TAF1A	0.413
WDR1	0.413
ZZZ3	0.413
DERL1	0.412
CEP57	0.412
ATP5D	0.411
SEC62	0.411
RFK	0.411
TBCB	0.411
EIF1AX	0.41
ELP3	0.41
RFT1	0.408
VPS41	0.408
GFER	0.408
GABPA	0.407
ATP5A1	0.406
UBQLN1	0.405
CBX3	0.405
COPS8	0.404
LSM10	0.404
RABIF	0.403
C21orf59	0.401
SUPV3L1	0.401
ZBTB44	0.401
SMARCD1	0.401
ARIH1	0.401
ELF2	0.4
SUGT1	0.4

Global Fraction of Cell Lines Where Essential: 591/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	22/28
blood	27/28
bone	24/25
breast	23/33
central nervous system	50/56
cervix	3/4
colorectal	15/17
esophagus	11/13
fibroblast	0/1
gastric	12/15
kidney	17/21
liver	17/20
lung	62/75
lymphocyte	12/14
ovary	22/26
pancreas	22/24
peripheral nervous system	10/16
plasma cell	7/15
prostate	1/1
skin	20/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	14/22
urinary tract	25/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 1512
Expression level (log2 read counts): 6.37

Expression Distribution

Pox MCEL
Methyltransf 18
Methyltransf 11

mRNA cap methyltransferase complex
mRNA (guanine-N7-)-methyltransferase activity
RNA 5-cap (guanine-N7)-methylation
RNA (guanine-N7)-methylation
mRNA cap binding complex
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
RNA methylation
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
fibrillar center
RNA modification
receptor complex
macromolecule methylation
methylation
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
RNA processing
cellular response to cytokine stimulus
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
RNA binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression