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Ask your administrator if you think this is wrong. ======= RNMT ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: RNMT * **<color #00a2e8>Official Name</color>**: RNA guanine-7 methyltransferase * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8731|8731]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43148|O43148]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RNMT&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RNMT|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603514|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: N/A * **<color #00a2e8>UniProt Summary</color>**: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884). {ECO:0000269|PubMed:10347220, ECO:0000269|PubMed:11114884, ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871, ECO:0000269|PubMed:9705270, ECO:0000269|PubMed:9790902}. <button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> |Pox MCEL| |Methyltransf 18| |Methyltransf 11| </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |mRNA cap methyltransferase complex| |mRNA (guanine-N7-)-methyltransferase activity| |RNA 5-cap (guanine-N7)-methylation| |RNA (guanine-N7)-methylation| |mRNA cap binding complex| |7-methylguanosine mRNA capping| |7-methylguanosine RNA capping| |RNA capping| |RNA methylation| |cellular response to leukemia inhibitory factor| |response to leukemia inhibitory factor| |fibrillar center| |RNA modification| |receptor complex| |macromolecule methylation| |methylation| |mRNA processing| |transcription by RNA polymerase II| |transcription, DNA-templated| |nucleic acid-templated transcription| |RNA biosynthetic process| |mRNA metabolic process| |RNA processing| |cellular response to cytokine stimulus| |nucleobase-containing compound biosynthetic process| |response to cytokine| |heterocycle biosynthetic process| |aromatic compound biosynthetic process| |organic cyclic compound biosynthetic process| |RNA binding| |cellular nitrogen compound biosynthetic process| |RNA metabolic process| |cellular macromolecule biosynthetic process| |macromolecule biosynthetic process| |gene expression| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.45| |[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.21| |[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.99| |[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.97| |[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.95| |[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.92| |[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.9| |[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.84| |[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311]]|-1.78| |[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.78| |[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.77| |[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.76| |[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.76| |[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.76| |[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.72| |[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.71| |[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.73| |[[:results:exp135|MS023 7μM R03 exp135]]|1.76| |[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.83| |[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.83| |[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.85| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86| |[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.87| |[[:results:exp19|Etoposide 1μM R00 exp19]]|1.88| |[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.94| |[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.94| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.04| |[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.06| |[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.08| |[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.19| |[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.24| |[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.26| |[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.4| |[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.51| |[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.56| |[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.61| |[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.64| |[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.72| |[[:results:exp96|BI-2536 0.02μM R03 exp96]]|3.01| |[[:results:exp93|DABN racemic mixture R03 exp93]]|3.29| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:t:thg1l|THG1L]]|0.717| |[[:human genes:r:rptor|RPTOR]]|0.711| |[[:human genes:g:gmppb|GMPPB]]|0.703| |[[:human genes:p:pmm2|PMM2]]|0.674| |[[:human genes:m:med16|MED16]]|0.671| |[[:human genes:a:alg1|ALG1]]|0.67| |[[:human genes:d:dpagt1|DPAGT1]]|0.666| |[[:human genes:h:hspd1|HSPD1]]|0.664| |[[:human genes:d:dohh|DOHH]]|0.65| |[[:human genes:g:gfpt1|GFPT1]]|0.646| |[[:human genes:g:gtf3c2|GTF3C2]]|0.642| |[[:human genes:g:gnb1l|GNB1L]]|0.64| |[[:human genes:r:rtcb|RTCB]]|0.628| |[[:human genes:o:oraov1|ORAOV1]]|0.625| |[[:human genes:p:polr3h|POLR3H]]|0.621| |[[:human genes:b:bap1|BAP1]]|0.621| |[[:human genes:c:csnk2b|CSNK2B]]|0.621| |[[:human genes:e:eif4e|EIF4E]]|0.611| |[[:human genes:a:alg13|ALG13]]|0.608| |[[:human genes:t:triap1|TRIAP1]]|0.607| |[[:human genes:d:dhps|DHPS]]|0.602| |[[:human genes:g:gtf3c4|GTF3C4]]|0.601| |[[:human genes:n:nars|NARS]]|0.601| |[[:human genes:p:pelo|PELO]]|0.597| |[[:human genes:a:aars|AARS]]|0.597| |[[:human genes:c:ccdc101|CCDC101]]|0.597| |[[:human genes:m:mtor|MTOR]]|0.597| |[[:human genes:t:trnt1|TRNT1]]|0.593| |[[:human genes:s:srp72|SRP72]]|0.593| |[[:human genes:a:alg2|ALG2]]|0.591| |[[:human genes:n:nae1|NAE1]]|0.591| |[[:human genes:g:gtf3c3|GTF3C3]]|0.59| |[[:human genes:t:tti2|TTI2]]|0.59| |[[:human genes:t:tti1|TTI1]]|0.59| |[[:human genes:a:alg5|ALG5]]|0.589| |[[:human genes:a:adsl|ADSL]]|0.589| |[[:human genes:r:rpp21|RPP21]]|0.587| |[[:human genes:u:uhrf1|UHRF1]]|0.577| |[[:human genes:u:uap1|UAP1]]|0.577| |[[:human genes:a:atp5j|ATP5J]]|0.576| |[[:human genes:w:wdr24|WDR24]]|0.574| |[[:human genes:s:srp68|SRP68]]|0.574| |[[:human genes:h:hars|HARS]]|0.573| |[[:human genes:t:tsen54|TSEN54]]|0.573| |[[:human genes:a:atxn10|ATXN10]]|0.572| |[[:human genes:c:cct7|CCT7]]|0.572| |[[:human genes:p:pam16|PAM16]]|0.571| |[[:human genes:e:exoc4|EXOC4]]|0.57| |[[:human genes:t:tgs1|TGS1]]|0.569| |[[:human genes:d:dad1|DAD1]]|0.568| |[[:human genes:v:vezt|VEZT]]|0.568| |[[:human genes:e:eprs|EPRS]]|0.565| |[[:human genes:y:yars|YARS]]|0.565| |[[:human genes:g:gtf3c6|GTF3C6]]|0.565| |[[:human genes:c:cbfb|CBFB]]|0.564| |[[:human genes:m:mars|MARS]]|0.563| |[[:human genes:m:meaf6|MEAF6]]|0.561| |[[:human genes:s:srp14|SRP14]]|0.56| |[[:human genes:o:osgep|OSGEP]]|0.559| |[[:human genes:e:eny2|ENY2]]|0.557| |[[:human genes:h:haus8|HAUS8]]|0.553| |[[:human genes:p:polr3b|POLR3B]]|0.552| |[[:human genes:d:ddx20|DDX20]]|0.551| |[[:human genes:u:utp23|UTP23]]|0.551| |[[:human genes:u:ube2g2|UBE2G2]]|0.55| |[[:human genes:u:uxt|UXT]]|0.548| |[[:human genes:r:rpn1|RPN1]]|0.548| |[[:human genes:p:ppp2r3c|PPP2R3C]]|0.542| |[[:human genes:m:mapk14|MAPK14]]|0.538| |[[:human genes:e:exoc3|EXOC3]]|0.538| |[[:human genes:d:dhdds|DHDDS]]|0.531| |[[:human genes:s:slc35b1|SLC35B1]]|0.527| |[[:human genes:m:med23|MED23]]|0.526| |[[:human genes:t:telo2|TELO2]]|0.525| |[[:human genes:s:sec61g|SEC61G]]|0.525| |[[:human genes:t:timm22|TIMM22]]|0.524| |[[:human genes:n:nsd1|NSD1]]|0.518| |[[:human genes:m:mllt1|MLLT1]]|0.517| |[[:human genes:c:casp9|CASP9]]|0.517| |[[:human genes:t:timm13|TIMM13]]|0.517| |[[:human genes:c:crcp|CRCP]]|0.515| |[[:human genes:z:znf259|ZNF259]]|0.514| |[[:human genes:v:vrk1|VRK1]]|0.513| |[[:human genes:t:trmt5|TRMT5]]|0.513| |[[:human genes:p:plaa|PLAA]]|0.511| |[[:human genes:z:zfx|ZFX]]|0.511| |[[:human genes:f:faf2|FAF2]]|0.511| |[[:human genes:v:vmp1|VMP1]]|0.51| |[[:human genes:b:bub3|BUB3]]|0.509| |[[:human genes:d:ddost|DDOST]]|0.509| |[[:human genes:a:alg14|ALG14]]|0.509| |[[:human genes:t:tmem41b|TMEM41B]]|0.508| |[[:human genes:t:tbca|TBCA]]|0.507| |[[:human genes:f:fnta|FNTA]]|0.505| |[[:human genes:o:otud5|OTUD5]]|0.505| |[[:human genes:c:cdipt|CDIPT]]|0.505| |[[:human genes:p:ppa2|PPA2]]|0.505| |[[:human genes:a:atp5o|ATP5O]]|0.503| |[[:human genes:s:seh1l|SEH1L]]|0.502| |[[:human genes:s:spcs2|SPCS2]]|0.501| |[[:human genes:t:tsen34|TSEN34]]|0.501| |[[:human genes:d:dnajc3|DNAJC3]]|0.5| |[[:human genes:t:taz|TAZ]]|0.5| |[[:human genes:t:trmt10a|TRMT10A]]|0.499| |[[:human genes:u:uba3|UBA3]]|0.498| |[[:human genes:t:ttc4|TTC4]]|0.496| |[[:human genes:p:phb|PHB]]|0.494| |[[:human genes:m:med4|MED4]]|0.494| |[[:human genes:h:hccs|HCCS]]|0.491| |[[:human genes:g:gtf2a2|GTF2A2]]|0.489| |[[:human genes:w:wars|WARS]]|0.488| |[[:human genes:v:vhl|VHL]]|0.486| |[[:human genes:d:dr1|DR1]]|0.486| |[[:human genes:t:tamm41|TAMM41]]|0.485| |[[:human genes:c:cars|CARS]]|0.485| |[[:human genes:l:lsm11|LSM11]]|0.485| |[[:human genes:l:lsmd1|LSMD1]]|0.483| |[[:human genes:n:nsmce1|NSMCE1]]|0.483| |[[:human genes:p:ppcs|PPCS]]|0.482| |[[:human genes:a:atp5b|ATP5B]]|0.482| |[[:human genes:g:gemin5|GEMIN5]]|0.481| |[[:human genes:t:thoc6|THOC6]]|0.48| |[[:human genes:s:shoc2|SHOC2]]|0.478| |[[:human genes:l:lamtor5|LAMTOR5]]|0.478| |[[:human genes:c:cmtr1|CMTR1]]|0.477| |[[:human genes:m:mad2l1|MAD2L1]]|0.477| |[[:human genes:t:trim28|TRIM28]]|0.476| |[[:human genes:z:zrsr2|ZRSR2]]|0.475| |[[:human genes:w:wdr59|WDR59]]|0.474| |[[:human genes:a:apaf1|APAF1]]|0.474| |[[:human genes:t:txnrd1|TXNRD1]]|0.473| |[[:human genes:k:kdsr|KDSR]]|0.472| |[[:human genes:x:xpo6|XPO6]]|0.472| |[[:human genes:e:elac2|ELAC2]]|0.472| |[[:human genes:p:pisd|PISD]]|0.472| |[[:human genes:t:txnl4b|TXNL4B]]|0.471| |[[:human genes:e:eef1e1|EEF1E1]]|0.47| |[[:human genes:s:sdha|SDHA]]|0.47| |[[:human genes:b:bak1|BAK1]]|0.468| |[[:human genes:f:fli1|FLI1]]|0.467| |[[:human genes:a:atp2a2|ATP2A2]]|0.466| |[[:human genes:s:snapc5|SNAPC5]]|0.466| |[[:human genes:s:ssbp2|SSBP2]]|0.465| |[[:human genes:p:ppp4c|PPP4C]]|0.465| |[[:human genes:g:gpn2|GPN2]]|0.464| |[[:human genes:s:sox7|SOX7]]|0.464| |[[:human genes:c:ctdnep1|CTDNEP1]]|0.463| |[[:human genes:s:spcs3|SPCS3]]|0.462| |[[:human genes:d:ddx55|DDX55]]|0.462| |[[:human genes:d:dkc1|DKC1]]|0.46| |[[:human genes:c:cep350|CEP350]]|0.459| |[[:human genes:n:naf1|NAF1]]|0.458| |[[:human genes:d:dctn6|DCTN6]]|0.458| |[[:human genes:u:ube2k|UBE2K]]|0.458| |[[:human genes:g:gtf3a|GTF3A]]|0.456| |[[:human genes:r:rbm14|RBM14]]|0.456| |[[:human genes:t:thoc3|THOC3]]|0.455| |[[:human genes:d:dolk|DOLK]]|0.455| |[[:human genes:e:eno1|ENO1]]|0.454| |[[:human genes:d:dhx29|DHX29]]|0.454| |[[:human genes:e:eif3f|EIF3F]]|0.453| |[[:human genes:t:tbp|TBP]]|0.453| |[[:human genes:r:rad1|RAD1]]|0.452| |[[:human genes:t:tprkb|TPRKB]]|0.452| |[[:human genes:x:xpot|XPOT]]|0.451| |[[:human genes:p:pik3r4|PIK3R4]]|0.45| |[[:human genes:r:romo1|ROMO1]]|0.449| |[[:human genes:p:pdap1|PDAP1]]|0.449| |[[:human genes:h:hmgb2|HMGB2]]|0.449| |[[:human genes:q:qars|QARS]]|0.448| |[[:human genes:l:lmo2|LMO2]]|0.447| |[[:human genes:t:ten1|TEN1]]|0.446| |[[:human genes:w:wdr82|WDR82]]|0.445| |[[:human genes:g:gemin6|GEMIN6]]|0.445| |[[:human genes:i:irf2bp2|IRF2BP2]]|0.444| |[[:human genes:r:rpe|RPE]]|0.443| |[[:human genes:a:actr10|ACTR10]]|0.443| |[[:human genes:t:tmed10|TMED10]]|0.442| |[[:human genes:a:alg6|ALG6]]|0.442| |[[:human genes:g:gemin8|GEMIN8]]|0.441| |[[:human genes:c:chchd4|CHCHD4]]|0.44| |[[:human genes:o:oip5|OIP5]]|0.44| |[[:human genes:d:dnajb11|DNAJB11]]|0.439| |[[:human genes:s:ssb|SSB]]|0.439| |[[:human genes:s:snf8|SNF8]]|0.439| |[[:human genes:t:tle4|TLE4]]|0.438| |[[:human genes:t:tbcd|TBCD]]|0.437| |[[:human genes:w:wdr92|WDR92]]|0.437| |[[:human genes:d:dpf2|DPF2]]|0.436| |[[:human genes:c:cycs|CYCS]]|0.436| |[[:human genes:a:abcf1|ABCF1]]|0.435| |[[:human genes:f:fgfr1op|FGFR1OP]]|0.434| |[[:human genes:n:nupl2|NUPL2]]|0.434| |[[:human genes:m:max|MAX]]|0.433| |[[:human genes:s:slc25a26|SLC25A26]]|0.433| |[[:human genes:a:abcb7|ABCB7]]|0.432| |[[:human genes:p:polr3c|POLR3C]]|0.432| |[[:human genes:p:pggt1b|PGGT1B]]|0.432| |[[:human genes:m:maml1|MAML1]]|0.432| |[[:human genes:u:ube2j1|UBE2J1]]|0.43| |[[:human genes:p:ptchd3|PTCHD3]]|0.43| |[[:human genes:i:id3|ID3]]|0.429| |[[:human genes:a:asxl2|ASXL2]]|0.429| |[[:human genes:u:ube2m|UBE2M]]|0.428| |[[:human genes:m:mbtps2|MBTPS2]]|0.427| |[[:human genes:z:zbtb11|ZBTB11]]|0.424| |[[:human genes:a:ago2|AGO2]]|0.424| |[[:human genes:k:kif14|KIF14]]|0.423| |[[:human genes:n:nxt1|NXT1]]|0.423| |[[:human genes:a:atf7ip|ATF7IP]]|0.423| |[[:human genes:c:crls1|CRLS1]]|0.422| |[[:human genes:l:lamtor4|LAMTOR4]]|0.422| |[[:human genes:d:dctn5|DCTN5]]|0.42| |[[:human genes:d:dicer1|DICER1]]|0.42| |[[:human genes:s:srprb|SRPRB]]|0.42| |[[:human genes:c:chordc1|CHORDC1]]|0.42| |[[:human genes:a:atp5h|ATP5H]]|0.419| |[[:human genes:e:ercc2|ERCC2]]|0.416| |[[:human genes:u:ube2l3|UBE2L3]]|0.415| |[[:human genes:g:gtf2h3|GTF2H3]]|0.415| |[[:human genes:d:derl2|DERL2]]|0.414| |[[:human genes:p:psmg4|PSMG4]]|0.414| |[[:human genes:t:taf1a|TAF1A]]|0.413| |[[:human genes:w:wdr1|WDR1]]|0.413| |[[:human genes:z:zzz3|ZZZ3]]|0.413| |[[:human genes:d:derl1|DERL1]]|0.412| |[[:human genes:c:cep57|CEP57]]|0.412| |[[:human genes:a:atp5d|ATP5D]]|0.411| |[[:human genes:s:sec62|SEC62]]|0.411| |[[:human genes:r:rfk|RFK]]|0.411| |[[:human genes:t:tbcb|TBCB]]|0.411| |[[:human genes:e:eif1ax|EIF1AX]]|0.41| |[[:human genes:e:elp3|ELP3]]|0.41| |[[:human genes:r:rft1|RFT1]]|0.408| |[[:human genes:v:vps41|VPS41]]|0.408| |[[:human genes:g:gfer|GFER]]|0.408| |[[:human genes:g:gabpa|GABPA]]|0.407| |[[:human genes:a:atp5a1|ATP5A1]]|0.406| |[[:human genes:u:ubqln1|UBQLN1]]|0.405| |[[:human genes:c:cbx3|CBX3]]|0.405| |[[:human genes:c:cops8|COPS8]]|0.404| |[[:human genes:l:lsm10|LSM10]]|0.404| |[[:human genes:r:rabif|RABIF]]|0.403| |[[:human genes:c:c21orf59|C21orf59]]|0.401| |[[:human genes:s:supv3l1|SUPV3L1]]|0.401| |[[:human genes:z:zbtb44|ZBTB44]]|0.401| |[[:human genes:s:smarcd1|SMARCD1]]|0.401| |[[:human genes:a:arih1|ARIH1]]|0.401| |[[:human genes:e:elf2|ELF2]]|0.4| |[[:human genes:s:sugt1|SUGT1]]|0.4| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 591/726 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|1/1| |909776.0|0/1| |bile duct|22/28| |blood|27/28| |bone|24/25| |breast|23/33| |central nervous system|50/56| |cervix|3/4| |colorectal|15/17| |esophagus|11/13| |fibroblast|0/1| |gastric|12/15| |kidney|17/21| |liver|17/20| |lung|62/75| |lymphocyte|12/14| |ovary|22/26| |pancreas|22/24| |peripheral nervous system|10/16| |plasma cell|7/15| |prostate|1/1| |skin|20/24| |soft tissue|6/7| |thyroid|2/2| |upper aerodigestive|14/22| |urinary tract|25/29| |uterus|2/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 1512 * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='RNMT Expression in NALM6 Cells: 6.37'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2025/12/10 20:19by 127.0.0.1