LMO2

Gene Information

Official Symbol: LMO2
Official Name: LIM domain only 2
Aliases and Previous Symbols: N/A
Entrez ID: 4005
UniProt: P25791
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 1μM R00 exp29	-3
Radicicol 0.16μM R05 exp242	-2.74
Rapamycin 10μM R00 exp30	-2.2
Selumetinib 20μM R02 exp81	-2.18
Nutlin-3A 1.6μM R06 exp294	-2.17
Hypoxia 5%O2 R04 exp191	-2.15
Sulforaphane 9μM R08 exp525	-2.15
Cycloheximide 0.02μM R00 exp14	-2.14
Rapamycin 0.001μM R08 exp429	-2.1
Arsenate 40μM R06 exp264	-1.86
Menadione 5μM R06 exp292	-1.85
Oligomycin-A 2μM R00 exp25	-1.77
Wortmannin 0.5μM R00 exp37	-1.75
Colchicine 0.009μM R05 exp215	-1.74
Bortezomib 0.005μM R00 exp6	-1.72
I-BRD9 4μM R07 exp365	-1.71
Rifampicin 10μM R00 exp32	-1.71
VER-155008 3.9μM R06 exp301	-1.71
Rapamycin 2μM R07 exp306	-1.7
42°C R08 exp539	1.71
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.76
PU-H71 1μM R08 exp515	1.86
CCT251545 20μM R07 exp326	1.94
Deferoxamine 11μM R07 exp350	2.13
BI-2536 0.0042μM R03 exp95	2.18

Gene	Correlation
LDB1	0.628
ERG	0.614
SSBP2	0.587
SOX7	0.549
CBFB	0.524
DOHH	0.523
LYL1	0.5
NSD1	0.494
FLI1	0.493
CCDC101	0.492
ID3	0.491
ZNF319	0.476
BAP1	0.468
RPTOR	0.46
AGO2	0.456
RNMT	0.447
TRMT10A	0.436
LSM11	0.435
PIAS4	0.432
THG1L	0.432
ZFX	0.428
XPO6	0.424
DPAGT1	0.418
MED16	0.416
ASB3	0.415
ATXN10	0.414
SCAF8	0.409
ZNF410	0.405
SRP14	0.401
PELO	0.401
TTC4	0.4

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	5/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14617
Expression level (log2 read counts): 3.43

Expression Distribution

cellular response to thyroid hormone stimulus
cofactor binding
mRNA transcription by RNA polymerase II
mRNA transcription
bHLH transcription factor binding
response to thyroid hormone
E-box binding
RNA polymerase II activating transcription factor binding
regulation of hematopoietic stem cell differentiation
regulation of hematopoietic progenitor cell differentiation
regulation of stem cell differentiation
transcription factor complex
RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
regulation of hemopoiesis
transcription by RNA polymerase II
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
response to hormone
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II
cellular response to endogenous stimulus
organic cyclic compound biosynthetic process
response to endogenous stimulus
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of immune system process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
regulation of cell differentiation