LMO2 [The Human Chemical-Genetic Interaction Map Project]

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======= LMO2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LMO2
  * **<color #00a2e8>Official Name</color>**: LIM domain only 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4005|4005]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25791|P25791]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LMO2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LMO2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180385|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to thyroid hormone stimulus|
|cofactor binding|
|mRNA transcription by RNA polymerase II|
|mRNA transcription|
|bHLH transcription factor binding|
|response to thyroid hormone|
|E-box binding|
|RNA polymerase II activating transcription factor binding|
|regulation of hematopoietic stem cell differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of stem cell differentiation|
|transcription factor complex|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|transcription by RNA polymerase II|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|response to hormone|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-3|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.74|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.2|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.18|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.17|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.15|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.15|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.14|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.1|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.86|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.77|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.74|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.72|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.71|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.71|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.71|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.71|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.94|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.13|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:ldb1|LDB1]]|0.628|
|[[:human genes:e:erg|ERG]]|0.614|
|[[:human genes:s:ssbp2|SSBP2]]|0.587|
|[[:human genes:s:sox7|SOX7]]|0.549|
|[[:human genes:c:cbfb|CBFB]]|0.524|
|[[:human genes:d:dohh|DOHH]]|0.523|
|[[:human genes:l:lyl1|LYL1]]|0.5|
|[[:human genes:n:nsd1|NSD1]]|0.494|
|[[:human genes:f:fli1|FLI1]]|0.493|
|[[:human genes:c:ccdc101|CCDC101]]|0.492|
|[[:human genes:i:id3|ID3]]|0.491|
|[[:human genes:z:znf319|ZNF319]]|0.476|
|[[:human genes:b:bap1|BAP1]]|0.468|
|[[:human genes:r:rptor|RPTOR]]|0.46|
|[[:human genes:a:ago2|AGO2]]|0.456|
|[[:human genes:r:rnmt|RNMT]]|0.447|
|[[:human genes:t:trmt10a|TRMT10A]]|0.436|
|[[:human genes:l:lsm11|LSM11]]|0.435|
|[[:human genes:p:pias4|PIAS4]]|0.432|
|[[:human genes:t:thg1l|THG1L]]|0.432|
|[[:human genes:z:zfx|ZFX]]|0.428|
|[[:human genes:x:xpo6|XPO6]]|0.424|
|[[:human genes:d:dpagt1|DPAGT1]]|0.418|
|[[:human genes:m:med16|MED16]]|0.416|
|[[:human genes:a:asb3|ASB3]]|0.415|
|[[:human genes:a:atxn10|ATXN10]]|0.414|
|[[:human genes:s:scaf8|SCAF8]]|0.409|
|[[:human genes:z:znf410|ZNF410]]|0.405|
|[[:human genes:s:srp14|SRP14]]|0.401|
|[[:human genes:p:pelo|PELO]]|0.401|
|[[:human genes:t:ttc4|TTC4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14617
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LMO2 Expression in NALM6 Cells: 3.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>