ZNF410

Entrez Summary: N/A
UniProt Summary: Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence. {ECO:0000269|PubMed:12370286}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Chlorpromazine 10μM R07 exp344	-2.08
TRAIL 50ng/ml R00 exp36	-2.08
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-2.07
TRAIL 5ng/ml R00 exp35	-2.07
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-2.05
THZ531 0.11μM R07 exp409	-2.04
I-BRD9 4μM R07 exp365	-1.98
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-1.95
Dimethyloxaloylglycine 100μM R05 exp229	-1.94
B02 10μM R08 exp453	-1.88
Lead acetate 2000μM R08 exp498 no dilution day6	-1.86
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.78
LB-100 2μM R05 exp210	-1.77
Selumetinib 20μM R02 exp81	-1.76
Azithromycin 100μM R08 exp452	-1.76
UM131593 0.2μM R03 exp106	2.21
Aminopterin 0.005μM R07 exp335	2.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific