Chlorpromazine 10μM R07 exp344

Antipsychotic, pleiotropic antagonist for dopamine, seratonin, histamine, adrenergic, muscarinic receptors, potassium and sodium channels, also disrupts clathrin-mediated endocytosis

Class / Subclass 1: Signal Transduction / GPCR Antagonist
Class / Subclass 2: Signal Transduction / Ion Channel Inhibitor
Class / Subclass 3: Organelle Function / Vesicule Trafficking Inhibitor

Compound References

PubChem Name: Chlorpromazine
Synonyms: N/A
CAS #: 50-53-3
PubChem CID: 2726
IUPAC: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
INCHI Name: InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
INCHI Key: ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Molecular Weight: 318.9
Canonical SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
Isomeric SMILES: N/A
Molecular Formula: C17H19ClN2S

Compound Supplier

Supplier Name: Combi-Blocks
Catalog #: QA-9445
Lot #: L45198

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H19ClN2S 319.10302; found 319.10309

Dose Response Curve

Platform ID: Chlorpromazine
Min: 0.1373; Max: 99.8449

IC	Concentration (µM)
IC10	N/A
IC20	7.8279
IC30	9.3304
IC40	10.7726
IC50	12.2908
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 07
Dose: 10µM
Days of incubation: 8
Doublings: 5.1
Numbers of reads: 20823277

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
12/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SLC5A3	-3.21	<0.01
PPWD1	-3.13	0.06
RAB7A	-3.11	<0.01
FLVCR1	-3.00	<0.01
TCF4	-2.98	<0.01
DAGLB	-2.65	0.03
SART3	-2.64	0.22
KIAA1432	-2.63	0.03
VKORC1L1	-2.55	0.03
FAM194B	-2.53	0.06
SCYL1	-2.52	0.03
ACTR3	-2.51	0.03
PPIP5K2	-2.51	0.03
PCYT1A	-2.47	0.04
RAB1B	-2.44	0.06
DERL1	-2.43	0.05
CHKA	-2.36	0.06
KIF18B	-2.36	0.06
NHLRC2	-2.34	0.10
DLGAP5	-2.30	0.06
COG7	-2.30	0.06
GMPPB	-2.29	0.31
ARL1	-2.26	0.08
MEIG1	-2.21	0.45
GAPDH	-2.13	0.40
DPAGT1	-2.13	0.15
TAS2R60	-2.11	0.16
ZNF259	-2.09	0.24
ZNF410	-2.08	0.17
ZSWIM8	-2.08	0.17
TGFBR3	1.88	0.66
TAF5	1.89	0.68
TRIM37	1.90	0.64
FBXO21	1.90	0.64
CHRNE	1.91	0.64
ZNF415	1.91	0.64
PDE4DIP	1.91	0.64
TSGA10	1.91	0.64
NDUFB10	1.91	0.64
DLAT	1.92	0.66
HMGXB3	1.96	0.64
ANKRD66	1.99	0.64
RELN	1.99	0.64
ZSCAN18	1.99	0.64
MICU2	2.00	0.64
EP400	2.00	0.64
ATP2B1	2.02	0.64
MGAT4C	2.04	0.64
MYC	2.05	0.68
ITSN2	2.05	0.64
RRM2	2.06	0.68
ATP5D	2.06	0.66
FGGY	2.08	0.64
ALAD	2.09	0.64
MTIF2	2.10	0.64
SLC25A32	2.13	0.64
HSPA5	2.15	0.68
POLE2	2.24	0.66
ITPK1	2.32	0.64
POLE	2.44	0.64

Screen	Correlation	Plot
FTY720 3μM R08 exp483	0.121	View
Thioridazine 5μM R08 exp530	0.12	View
Ibrutinib 10μM R08 exp442	0.101	View
NN-Dimethylsphingosine 2.5μM R08 exp508	0.085	View
Wiskostatin 3μM R07 exp422	0.085	View
Prochlorperazine 5.2μM R02 exp77	0.081	View
EPZ-5676 30μM R05 exp233	0.079	View
Clomiphene 4.4μM R02 exp68	0.077	View
SB203580 25μM R03 exp149	0.064	View
IU1-47 25μM R04 exp182	0.062	View
WYE-354 6μM R02 exp90	0.062	View
Q15 1 to 2μM on day4 R04 exp164	0.06	View
Nicotine 3000μM R08 exp510	0.053	View
FK-506 5μM R07 exp358	0.053	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.052	View
Cyclosporin-A 3μM R07 exp348	0.052	View
FK-506 30μM R07 exp359	0.051	View
L-74142 5μM R03 exp131	0.051	View
UNC1999 2μM R03 exp155	0.051	View
BS-181 20μM R08 exp461	0.133	View
CB-839 10μM R05 exp224	0.075	View
Cannabidiol 13μM R08 exp465	0.072	View
Bisphenol F 50μM R08 exp457	0.071	View
Chloroquine 32μM R08 exp470	0.067	View
CCT251545 20μM R07 exp326	0.066	View
CFI-400945 25μM R08 exp469	0.062	View
Bisphenol A 100μM R06 exp269	0.059	View
B02 10μM R08 exp453	0.056	View
Bafilomycin-A1 0.009μM R08 exp454	0.053	View
BH1 1μM R04 exp169	0.053	View
Azithromycin 100μM R08 exp452	0.053	View
A-395 10μM R05 exp218	0.053	View
Cannabidiol 20μM R08 exp466	0.052	View

Chlorpromazine 10μM R07 exp344

Mechanism of Action

Technical Notes

Compound References

Compound Supplier

Compound Characterization

Dose Response Curve

Screen Summary

Screen Results