Chlorpromazine 10μM R07 exp344 [The Human Chemical-Genetic Interaction Map Project]

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====== Chlorpromazine 10μM R07 exp344 ======
==== Mechanism of Action ====
Antipsychotic, pleiotropic antagonist for dopamine, seratonin, histamine, adrenergic, muscarinic receptors, potassium and sodium channels, also disrupts clathrin-mediated endocytosis
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / GPCR Antagonist
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / Ion Channel Inhibitor
  * **<color #00a2e8>Class / Subclass 3:</color>** Organelle Function / Vesicule Trafficking Inhibitor


==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Compound References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Chlorpromazine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 50-53-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/2726|2726]]
    * **<color #00a2e8>IUPAC:</color>** %%3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
    * **<color #00a2e8>INCHI Key:</color>** ZPEIMTDSQAKGNT-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 318.9
    * **<color #00a2e8>Canonical SMILES:</color>** CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C17H19ClN2S
{{:chemogenomics:structures:chem-0202.svg?nolink}}
</panel>


<panel title='Compound Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Combi-Blocks
    * **<color #00a2e8>Catalog #:</color>** QA-9445
    * **<color #00a2e8>Lot #:</color>** L45198
</panel>


<panel title='Compound Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C17H19ClN2S 319.10302; found 319.10309
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Chlorpromazine
    * **<color #00a2e8>Min:</color>** 0.1373; **<color #00a2e8>Max:</color>** 99.8449
{{:chemogenomics:dose_response:dr_422.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |7.8279    |
| IC30  |9.3304    |
| IC40  |10.7726    |
| IC50  |12.2908    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 10µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.1
    * **<color #00a2e8>Numbers of reads</color>**: 20823277


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|12/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Chlorpromazine_10uM_Round-7_exp344.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Chlorpromazine 10μM R07 exp344'>
{{:chemogenomics:cranks_plots:exp344.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC5A3|SLC5A3]]|-3.21|<0.01|
|[[:human_genes:P:PPWD1|PPWD1]]|-3.13|0.06|
|[[:human_genes:R:RAB7A|RAB7A]]|-3.11|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.00|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-2.98|<0.01|
|[[:human_genes:D:DAGLB|DAGLB]]|-2.65|0.03|
|[[:human_genes:S:SART3|SART3]]|-2.64|0.22|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.63|0.03|
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-2.55|0.03|
|[[:human_genes:F:FAM194B|FAM194B]]|-2.53|0.06|
|[[:human_genes:S:SCYL1|SCYL1]]|-2.52|0.03|
|[[:human_genes:A:ACTR3|ACTR3]]|-2.51|0.03|
|[[:human_genes:P:PPIP5K2|PPIP5K2]]|-2.51|0.03|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.47|0.04|
|[[:human_genes:R:RAB1B|RAB1B]]|-2.44|0.06|
|[[:human_genes:D:DERL1|DERL1]]|-2.43|0.05|
|[[:human_genes:C:CHKA|CHKA]]|-2.36|0.06|
|[[:human_genes:K:KIF18B|KIF18B]]|-2.36|0.06|
|[[:human_genes:N:NHLRC2|NHLRC2]]|-2.34|0.10|
|[[:human_genes:D:DLGAP5|DLGAP5]]|-2.30|0.06|
|[[:human_genes:C:COG7|COG7]]|-2.30|0.06|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.29|0.31|
|[[:human_genes:A:ARL1|ARL1]]|-2.26|0.08|
|[[:human_genes:M:MEIG1|MEIG1]]|-2.21|0.45|
|[[:human_genes:G:GAPDH|GAPDH]]|-2.13|0.40|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.13|0.15|
|[[:human_genes:T:TAS2R60|TAS2R60]]|-2.11|0.16|
|[[:human_genes:Z:ZNF259|ZNF259]]|-2.09|0.24|
|[[:human_genes:Z:ZNF410|ZNF410]]|-2.08|0.17|
|[[:human_genes:Z:ZSWIM8|ZSWIM8]]|-2.08|0.17|
|[[:human_genes:T:TGFBR3|TGFBR3]]|1.88|0.66|
|[[:human_genes:T:TAF5|TAF5]]|1.89|0.68|
|[[:human_genes:T:TRIM37|TRIM37]]|1.90|0.64|
|[[:human_genes:F:FBXO21|FBXO21]]|1.90|0.64|
|[[:human_genes:C:CHRNE|CHRNE]]|1.91|0.64|
|[[:human_genes:Z:ZNF415|ZNF415]]|1.91|0.64|
|[[:human_genes:P:PDE4DIP|PDE4DIP]]|1.91|0.64|
|[[:human_genes:T:TSGA10|TSGA10]]|1.91|0.64|
|[[:human_genes:N:NDUFB10|NDUFB10]]|1.91|0.64|
|[[:human_genes:D:DLAT|DLAT]]|1.92|0.66|
|[[:human_genes:H:HMGXB3|HMGXB3]]|1.96|0.64|
|[[:human_genes:A:ANKRD66|ANKRD66]]|1.99|0.64|
|[[:human_genes:R:RELN|RELN]]|1.99|0.64|
|[[:human_genes:Z:ZSCAN18|ZSCAN18]]|1.99|0.64|
|[[:human_genes:M:MICU2|MICU2]]|2.00|0.64|
|[[:human_genes:E:EP400|EP400]]|2.00|0.64|
|[[:human_genes:A:ATP2B1|ATP2B1]]|2.02|0.64|
|[[:human_genes:M:MGAT4C|MGAT4C]]|2.04|0.64|
|[[:human_genes:M:MYC|MYC]]|2.05|0.68|
|[[:human_genes:I:ITSN2|ITSN2]]|2.05|0.64|
|[[:human_genes:R:RRM2|RRM2]]|2.06|0.68|
|[[:human_genes:A:ATP5D|ATP5D]]|2.06|0.66|
|[[:human_genes:F:FGGY|FGGY]]|2.08|0.64|
|[[:human_genes:A:ALAD|ALAD]]|2.09|0.64|
|[[:human_genes:M:MTIF2|MTIF2]]|2.10|0.64|
|[[:human_genes:S:SLC25A32|SLC25A32]]|2.13|0.64|
|[[:human_genes:H:HSPA5|HSPA5]]|2.15|0.68|
|[[:human_genes:P:POLE2|POLE2]]|2.24|0.66|
|[[:human_genes:I:ITPK1|ITPK1]]|2.32|0.64|
|[[:human_genes:P:POLE|POLE]]|2.44|0.64|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.121|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.12|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.101|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.085|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.085|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.081|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.079|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.077|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.064|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|0.062|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.062|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.06|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|0.053|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp358|FK-506 5μM R07 exp358]]|0.053|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.052|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|0.052|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.051|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|0.051|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.133|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp224|CB-839 10μM R05 exp224]]|0.075|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|0.072|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|0.071|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|0.067|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.066|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.062|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.059|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.056|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.053|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.053|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.053|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp218|A-395 10μM R05 exp218]]|0.053|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.052|<button type="primary" size="small" modal="33">View</button>|
</modal>


<modal id="1" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  FTY720 3μM R08 exp483">
{{:chemogenomics:comparison_plots:exp344_vs_exp483.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp344_vs_exp530.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp344_vs_exp442.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp344_vs_exp508.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp344_vs_exp422.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp344_vs_exp77.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp233_vs_exp344.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Clomiphene 4.4μM R02 exp68">
{{:chemogenomics:comparison_plots:exp344_vs_exp68.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp344.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp344.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp344_vs_exp90.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp344.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Nicotine 3000μM R08 exp510">
{{:chemogenomics:comparison_plots:exp344_vs_exp510.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  FK-506 5μM R07 exp358">
{{:chemogenomics:comparison_plots:exp344_vs_exp358.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp344_vs_exp445.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  Cyclosporin-A 3μM R07 exp348">
{{:chemogenomics:comparison_plots:exp344_vs_exp348.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp344_vs_exp359.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  L-74142 5μM R03 exp131">
{{:chemogenomics:comparison_plots:exp131_vs_exp344.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  UNC1999 2μM R03 exp155">
{{:chemogenomics:comparison_plots:exp155_vs_exp344.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BS-181 20μM R08 exp461  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp461.png?nolink |}}
</modal>

<modal id="21" size="lg" title="CB-839 10μM R05 exp224  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp224_vs_exp344.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp465.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Bisphenol F 50μM R08 exp457  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp457.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Chloroquine 32μM R08 exp470  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp470.png?nolink |}}
</modal>

<modal id="25" size="lg" title="CCT251545 20μM R07 exp326  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp326_vs_exp344.png?nolink |}}
</modal>

<modal id="26" size="lg" title="CFI-400945 25μM R08 exp469  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp469.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp269_vs_exp344.png?nolink |}}
</modal>

<modal id="28" size="lg" title="B02 10μM R08 exp453  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp453.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp454.png?nolink |}}
</modal>

<modal id="30" size="lg" title="BH1 1μM R04 exp169  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp169_vs_exp344.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Azithromycin 100μM R08 exp452  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp452.png?nolink |}}
</modal>

<modal id="32" size="lg" title="A-395 10μM R05 exp218  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp218_vs_exp344.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Cannabidiol 20μM R08 exp466  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp466.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>