A-395 10μM R05 exp218

Mechanism of Action

Inhibits EED subunit of PRC2 complex, blocks H3K27me3

  • Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor

Technical Notes

Compound References

  • PubChem Name: (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]pyrrolidin-3-amine
  • Synonyms: N/A
  • CAS #: 2089148-72-9
  • PubChem CID: 123132213
  • IUPAC: (3R,4S)-1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-(4-methylsulfonylpiperazin-1-yl)phenyl]pyrrolidin-3-amine
  • INCHI Name: InChI=1S/C26H35FN4O2S/c1-28(2)25-18-30(24-12-9-20-5-4-6-23(27)26(20)24)17-22(25)19-7-10-21(11-8-19)29-13-15-31(16-14-29)34(3,32)33/h4-8,10-11,22,24-25H,9,12-18H2,1-3H3/t22-,24?,25+/m1/s1
  • INCHI Key: REVJNSVNICWODC-KIDMSAQOSA-N
  • Molecular Weight: 486.6
  • Canonical SMILES: CN(C)C1CN(CC1C2=CC=C(C=C2)N3CCN(CC3)S(=O)(=O)C)C4CCC5=C4C(=CC=C5)F
  • Isomeric SMILES: CN(C)[C@H]1CN(C[C@@H]1C2=CC=C(C=C2)N3CCN(CC3)S(=O)(=O)C)C4CCC5=C4C(=CC=C5)F
  • Molecular Formula: C26H35FN4O2S

Compound Supplier

  • Supplier Name: Structural Genomics Consortium
  • Catalog #: N/A
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C26H35FN4O2S 487.25375; found 487.25529

Dose Response Curve

  • Platform ID: A395
  • Min: 1.7640; Max: 20.2623





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 05
  • Dose: 10µM
  • Days of incubation: 8
  • Doublings: 6.5
  • Numbers of reads: 16223252

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
4/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1