FOXI1

Entrez Summary: This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017].
UniProt Summary: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
A-395 10μM R05 exp218	-2.87
S-trityl-L-cysteine 0.5μM R05 exp243	-2.06
B02 10μM R08 exp453	-2.02
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.88
UNC2400 2μM R03 exp156	-1.86
RO-3306 3 to 4μM on day4 R04 exp165	-1.8
CAY10603 0.55μM R08 exp467	-1.78
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	-1.74
Nifuroxazide 5μM R03 exp102	-1.74
BI-6727 0.001μM R01 exp42	-1.71
Dynasore 7μM R08 exp436	1.81
Rifampicin 10μM R00 exp32	2

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DNA binding, bending
inner ear morphogenesis
ear morphogenesis
inner ear development
transcription regulatory region DNA binding
ear development
sensory organ morphogenesis
embryonic organ morphogenesis
sequence-specific DNA binding
embryonic organ development
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
embryonic morphogenesis
embryo development ending in birth or egg hatching
DNA-binding transcription factor activity
intracellular membrane-bounded organelle
nucleolus
animal organ morphogenesis
embryo development
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process