FOXI1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXI1
  * **<color #00a2e8>Official Name</color>**: forkhead box I1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2299|2299]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12951|Q12951]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601093|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding, bending|
|inner ear morphogenesis|
|ear morphogenesis|
|inner ear development|
|transcription regulatory region DNA binding|
|ear development|
|sensory organ morphogenesis|
|embryonic organ morphogenesis|
|sequence-specific DNA binding|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|embryonic morphogenesis|
|embryo development ending in birth or egg hatching|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|nucleolus|
|animal organ morphogenesis|
|embryo development|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.87|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.06|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.02|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.88|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.86|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|-1.8|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.78|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.74|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.74|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.81|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12223
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXI1 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>