UNC2400 2μM R03 exp156
Mechanism of Action
Inactive control for UNC1999 (EZH2 inhibitor)
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Compound References
- PubChem Name: N-[(1,6-Dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
- Synonyms: N/A
- CAS #: 1433200-49-7
- PubChem CID: 91691116
- IUPAC: N-[(1,6-dimethyl-2-oxo-4-propylpyridin-3-yl)methyl]-N-methyl-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
- INCHI Name: InChI=1S/C35H47N7O2/c1-9-10-26-17-25(6)39(8)35(44)31(26)22-38(7)34(43)29-18-28(19-32-30(29)21-37-42(32)24(4)5)27-11-12-33(36-20-27)41-15-13-40(14-16-41)23(2)3/h11-12,17-21,23-24H,9-10,13-16,22H2,1-8H3
- INCHI Key: IFSQHIRDVVFJSQ-UHFFFAOYSA-N
- Molecular Weight: 597.8
- Canonical SMILES: CCCC1=C(C(=O)N(C(=C1)C)C)CN(C)C(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C(C)C)C(C)C
- Isomeric SMILES: N/A
- Molecular Formula: C35H47N7O2
Compound Supplier
- Supplier Name: Structural Genomics Consortium
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C35H47N7O2 598.3864; found 598.38856
Dose Response Curve
- Platform ID: UNC2400
- Min: -2.6809; Max: 49.0595
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 2.1354 |
| IC30 | 6.8765 |
| IC40 | 17.9352 |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 2µM
- Days of incubation: 8
- Doublings: 7.9
- Numbers of reads: 10345192
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
UNC2400 2μM R03 exp156
