RPL8
Gene Information
- Official Symbol: RPL8
- Official Name: ribosomal protein L8
- Aliases and Previous Symbols: N/A
- Entrez ID: 6132
- UniProt: P62917
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the large ribosomal subunit. {ECO:0000305|PubMed:12962325}.
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L2 |
| Ribosomal L2 C |
GO Terms
| polysomal ribosome |
| rRNA binding |
| cytosolic large ribosomal subunit |
| cytoplasmic translation |
| postsynapse |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| viral transcription |
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| viral gene expression |
| protein localization to endoplasmic reticulum |
| translational initiation |
| protein targeting to membrane |
| structural constituent of ribosome |
| nuclear-transcribed mRNA catabolic process |
| mRNA catabolic process |
| RNA catabolic process |
| postsynaptic density |
| establishment of protein localization to membrane |
| protein targeting |
| nucleobase-containing compound catabolic process |
| translation |
| peptide biosynthetic process |
| focal adhesion |
| establishment of protein localization to organelle |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| protein localization to membrane |
| organic cyclic compound catabolic process |
| amide biosynthetic process |
| peptide metabolic process |
| mRNA metabolic process |
| viral process |
| protein localization to organelle |
| symbiotic process |
| cellular amide metabolic process |
| interspecies interaction between organisms |
| cellular macromolecule catabolic process |
| intracellular protein transport |
| macromolecule catabolic process |
| RNA binding |
| organonitrogen compound biosynthetic process |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| TCEB3C | 0.489 |
| TCEB3CL | 0.469 |
| PSMC5 | 0.458 |
| RPL35 | 0.456 |
| ADRM1 | 0.451 |
| RFC1 | 0.445 |
| PSMC1 | 0.443 |
| NARFL | 0.441 |
| PPM1D | 0.44 |
| VPS28 | 0.44 |
| PSMB4 | 0.438 |
| TCEB3CL2 | 0.436 |
| NELFA | 0.433 |
| PSMA7 | 0.432 |
| TSPY8 | 0.43 |
| UTP3 | 0.425 |
| CDC73 | 0.422 |
| VASN | 0.42 |
| SUPT5H | 0.417 |
| MBTD1 | 0.416 |
| PSMA6 | 0.416 |
| PSMD11 | 0.415 |
| PSMD1 | 0.414 |
| BRD2 | 0.413 |
| NUP160 | 0.406 |
| FAM160A1 | 0.405 |
| RPS12 | 0.404 |
| CHMP4B | 0.403 |
| OR10G3 | 0.402 |
| DTL | 0.402 |
| CDCA3 | 0.401 |
| POLR1B | 0.401 |
| EXOSC9 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 737/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 16/16 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 8
- Expression level (log2 read counts): 9.11
Expression Distribution
RPL8 Expression in NALM6 Cells: 9.11
