NUP160

Gene Information

Official Symbol: NUP160
Official Name: nucleoporin 160
Aliases and Previous Symbols: N/A
Entrez ID: 23279
UniProt: Q12769
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in poly(A)+ RNA transport. {ECO:0000269|PubMed:11684705}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Deferoxamine 11μM R07 exp350	-2.57
CI-1040 9.5μM R08 exp472	-2.3
Tanespimycin 14μM R08 exp527	-2.3
BI-6727 0.04μM R03 exp98	-1.97
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.79
MLN-4924 0.2μM R00 exp21	-1.72
Asunaprenir 3μM R07 exp336	1.7
YM155 0.0002μM R01 exp61	1.7
WNT3A 44ng/ml R08 exp537	1.73
MS094 2μM R03 exp136	1.76
Pyronaridine 1μM R06 exp295	1.81
Menadione 5μM R06 exp292	1.84
Rapamycin 2μM R07 exp306	1.85
All-trans-Retinoic-Acid 40μM R07 exp334	1.88
CAY10603 0.55μM R08 exp467	1.94
CCT251545 0.2μM R06 exp271	1.96
A-395N 10μM R05 exp219	1.97
39°C R06 exp303	2.05
Tunicamycin 0.04μM R07 exp418	2.07
BRD2 inhibitor II 20μM R07 exp341	2.08
BAY-598 4μM R05 exp220	2.11
PF-06409577 20μM R07 exp389	2.11
Cidofovir 10μM R07 exp345	2.18
Deguelin 0.15μM R05 exp209	2.23
A-196 10μM R03 exp114	2.24
Trametinib 10μM R02 exp83	2.25
UNC1999 2μM R03 exp155	2.42
HMS-I2 1μM R06 exp286	2.45
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.64
Cyclosporin-A 3μM R07 exp348	2.82

Gene	Correlation
PSMB4	0.593
COPG1	0.559
TCEB3C	0.551
NPIPB5	0.538
PRIM1	0.537
CDC73	0.534
TCEB3CL2	0.529
VASN	0.529
TCEB3CL	0.528
SLC6A17	0.527
SUPT5H	0.524
TICRR	0.523
DTL	0.522
C1QTNF9B	0.511
CHD4	0.51
NUPL1	0.509
POLE	0.507
C14orf93	0.506
PSMD14	0.502
RPL35	0.5
SEC13	0.498
CBWD3	0.498
CBWD5	0.494
PSMA6	0.494
PSMD3	0.493
LRR1	0.492
POLA1	0.491
ARCN1	0.487
NFATC4	0.485
MT1E	0.482
PSMB2	0.481
PWP2	0.48
CBWD6	0.479
PSMC2	0.479
NUP85	0.478
ATP6V1C1	0.478
CDC45	0.477
RRP7A	0.475
PSMA7	0.473
SNRPA1	0.472
SART1	0.472
RBBP5	0.471
INTS5	0.469
PSMC5	0.469
POLR2F	0.469
TBC1D3H	0.469
COPZ1	0.468
EIF4A3	0.467
RPS2	0.464
UPF1	0.464
NARFL	0.463
HAP1	0.462
CHAF1A	0.462
CGB2	0.461
RAD51	0.461
CMYA5	0.459
RBM39	0.459
AHCTF1	0.459
ZNF830	0.459
VPS28	0.456
PSMD2	0.455
CCNA2	0.455
SF3A1	0.454
PAN3	0.454
SLC4A1	0.453
HIST1H2BE	0.453
AQR	0.453
ORC1	0.452
COPB1	0.451
STIL	0.45
DOCK6	0.449
OSBP	0.448
INTS6	0.448
TWISTNB	0.448
AAMP	0.448
GAR1	0.447
LOC643669	0.446
TBC1D3C	0.444
CDC6	0.444
COPA	0.443
SSH2	0.443
RPSA	0.443
LAD1	0.443
TBC1D3G	0.442
CACTIN	0.442
KRT78	0.442
BRD2	0.441
DDX56	0.44
TFIP11	0.44
NCAPG	0.44
HIST2H3C	0.439
ISCU	0.439
COPE	0.439
HIST2H3A	0.439
ACSF2	0.438
CCDC64B	0.437
ZNF655	0.436
NUP205	0.436
TPX2	0.435
WDR75	0.435
MED17	0.434
TSG101	0.434
DIDO1	0.434
TAGLN	0.434
RIOK2	0.434
PLK1	0.432
SLC38A7	0.432
BOD1L1	0.432
CKAP5	0.431
NUP153	0.43
PSMD11	0.429
RAD21	0.429
EXOSC9	0.429
ANKLE2	0.429
PAF1	0.428
TBC1D3F	0.427
PSMD1	0.427
NUP155	0.425
UBE2Q2L	0.425
FAM25B	0.425
DNM2	0.425
PSMB3	0.424
RFC1	0.424
PLRG1	0.423
ZNF148	0.423
KPNB1	0.423
EXOSC5	0.421
TP53TG3B	0.42
TP53TG3	0.42
INTS1	0.419
FAM86B2	0.419
TP53TG3C	0.419
POLR2J3	0.419
DDTL	0.418
TINF2	0.418
KIAA1211	0.416
SMG1	0.416
POLA2	0.416
HNRNPC	0.415
SF3A3	0.415
TYMS	0.415
ATP6V0C	0.415
ALDH1B1	0.413
KCTD17	0.413
TIMELESS	0.413
ATP6V0B	0.412
POLR2L	0.412
FTSJ3	0.411
PRPF8	0.411
CHCHD3	0.411
EXOSC6	0.411
DDX23	0.411
KIAA0947	0.411
PIGS	0.41
WDR87	0.41
NUFIP2	0.41
GOLGA6L4	0.41
IGFN1	0.409
GOLGA6A	0.409
GOLGA6L3	0.408
USP35	0.407
AATF	0.407
ATP13A1	0.407
RPS19BP1	0.407
NPIPB15	0.407
RPL8	0.406
NCKAP1L	0.406
C2orf27B	0.406
XAB2	0.406
ORC6	0.404
RFFL	0.404
SF3B2	0.403
CWC22	0.402
SNIP1	0.402
NSF	0.402
WDR61	0.401
RRN3	0.401
DDX41	0.401
NAPA	0.401
JUND	0.4
PARP3	0.4

Global Fraction of Cell Lines Where Essential: 203/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	5/28
bone	10/26
breast	16/33
central nervous system	9/56
cervix	1/4
colorectal	5/17
esophagus	2/13
fibroblast	0/1
gastric	4/16
kidney	2/21
liver	7/20
lung	26/75
lymphocyte	5/16
ovary	6/26
pancreas	9/24
peripheral nervous system	6/16
plasma cell	3/15
prostate	1/1
skin	6/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	4/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 954
Expression level (log2 read counts): 8.13

Expression Distribution

nuclear pore outer ring
structural constituent of nuclear pore
tRNA-containing ribonucleoprotein complex export from nucleus
tRNA export from nucleus
tRNA transport
ncRNA export from nucleus
intracellular transport of virus
host cell
transport of virus
protein sumoylation
multi-organism localization
multi-organism transport
nuclear pore
regulation of cellular response to heat
regulation of glycolytic process
kinetochore
regulation of gene silencing by miRNA
regulation of carbohydrate catabolic process
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
mRNA-containing ribonucleoprotein complex export from nucleus
mRNA export from nucleus
viral transcription
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
nephron development
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
viral gene expression
regulation of gene silencing
protein export from nucleus
mRNA transport
regulation of generation of precursor metabolites and energy
nuclear export
nuclear envelope
RNA transport
nucleic acid transport
establishment of RNA localization