ZNF148

Gene Information

Official Symbol: ZNF148
Official Name: zinc finger protein 148
Aliases and Previous Symbols: N/A
Entrez ID: 7707
UniProt: Q9UQR1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017].
UniProt Summary: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.67
DABN 20μM R00 exp17	-2.02
Nocodazole 0.2μM R00 exp24	-1.98
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.94
Brefeldin A 0.02μM R00 exp8	-1.92
BI-6727 0.04μM R03 exp98	-1.9
MLN-4924 0.2μM R00 exp21	-1.84
JQ1 0.8μM R08 exp435	-1.81
SB743921 0.001μM R05 exp244	-1.75
RO-3307 4.7μM R02 exp80	-1.74
TIC10 10μM R08 exp532	-1.72
BI-6727 0.0125μM R03 exp97	1.7
VER-155008 3.9μM R06 exp301	1.71
Dimethyloxaloylglycine 100μM R05 exp229	1.73
Dexamethasone 0.006μM R07 exp351	1.74
Dimethyloxaloylglycine 11μM R07 exp314	1.74
Lead acetate 2000μM R08 exp497	1.77
VHL-ligand-1 20μM R07 exp421	1.81
All-trans-Retinoic-Acid 8μM R07 exp333	1.85
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.85
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.86
Wiskostatin 3μM R07 exp422	1.91
Oligomycin-A 2μM R00 exp25	1.93
Tunicamycin 0.04μM R07 exp418	2.01
Tubacin 1.6μM R07 exp416	2.02
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.05
Bisphenol S 100μM R08 exp458	2.11
LB-100 2μM R05 exp210	2.11
Bortezomib 0.005μM R00 exp6	2.21
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.26
I-BRD9 4μM R07 exp365	2.58
MK2206 4μM R08 exp504	2.7
Hypoxia 5%O2 R04 exp191	2.95

Gene	Correlation
RNF113A	0.51
SETD1A	0.477
NUFIP2	0.465
MEMO1	0.459
CDC73	0.459
HGC6.3	0.458
EIF4B	0.456
PAF1	0.455
ISCU	0.452
EXOSC6	0.449
CDK8	0.448
ORC6	0.446
FAM122A	0.445
TFIP11	0.441
ATP6V1C1	0.438
NUP85	0.43
RBM39	0.428
NUP160	0.423
PLRG1	0.414
TAGLN	0.411
SAP30BP	0.41
EIF3G	0.41
RSF1	0.41
CDC6	0.408
BOD1L1	0.406
CACTIN	0.406
PRIM1	0.405
CDC5L	0.405
CHD4	0.404
KDM6A	0.404

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18921
Expression level (log2 read counts): 5.84

Expression Distribution

substantia nigra development
cellular defense response
neural nucleus development
midbrain development
transcription regulatory region DNA binding
DNA-binding transcription repressor activity, RNA polymerase II-specific
sequence-specific DNA binding
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
gamete generation
brain development
head development
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
negative regulation of transcription by RNA polymerase II
central nervous system development
Golgi apparatus
multi-organism reproductive process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated