BOD1L1

Entrez Summary: N/A
UniProt Summary: Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

condensed chromosome outer kinetochore
replication fork processing
protein phosphatase 2A binding
protein phosphatase inhibitor activity
spindle microtubule
DNA-dependent DNA replication maintenance of fidelity
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
DNA-dependent DNA replication
spindle pole
chromosome
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
DNA replication
negative regulation of hydrolase activity
centrosome
DNA repair
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of catalytic activity
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process