BOD1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= BOD1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BOD1L1
  * **<color #00a2e8>Official Name</color>**: biorientation of chromosomes in cell division 1 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=259282|259282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFC6|Q8NFC6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BOD1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BOD1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616746|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705). {ECO:0000269|PubMed:26166705}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COMPASS-Shg1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed chromosome outer kinetochore|
|replication fork processing|
|protein phosphatase 2A binding|
|protein phosphatase inhibitor activity|
|spindle microtubule|
|DNA-dependent DNA replication maintenance of fidelity|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|DNA-dependent DNA replication|
|spindle pole|
|chromosome|
|regulation of protein dephosphorylation|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|DNA replication|
|negative regulation of hydrolase activity|
|centrosome|
|DNA repair|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.18|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.95|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.85|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.78|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.85|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.86|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ckap5|CKAP5]]|0.459|
|[[:human genes:s:setd1a|SETD1A]]|0.445|
|[[:human genes:c:cdc73|CDC73]]|0.433|
|[[:human genes:n:nup160|NUP160]]|0.432|
|[[:human genes:p:paf1|PAF1]]|0.43|
|[[:human genes:r:rpl38|RPL38]]|0.421|
|[[:human genes:d:dido1|DIDO1]]|0.414|
|[[:human genes:z:znf655|ZNF655]]|0.408|
|[[:human genes:z:znf148|ZNF148]]|0.406|
|[[:human genes:c:cnot1|CNOT1]]|0.402|
|[[:human genes:z:zfand5|ZFAND5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BOD1L1 Expression in NALM6 Cells: 7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>