Dimethyloxaloylglycine 100μM R05 exp229 [The Human Chemical-Genetic Interaction Map Project]

Prolylhydroxylase inhibitor, induces HIF-1α accumulation

Class / Subclass 1: Metabolism / Metabolic Enzyme Inhibitor
Class / Subclass 2: Signal Transduction / Other inhibitor

Compound References

PubChem Name: Dimethyloxalylglycine
Synonyms: Dimethyloxallyl Glycine
CAS #: 89464-63-1
PubChem CID: 560326
IUPAC: methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
INCHI Name: InChI=1S/C6H9NO5/c1-11-4(8)3-7-5(9)6(10)12-2/h3H2,1-2H3,(H,7,9)
INCHI Key: BNJOZDZCRHCODO-UHFFFAOYSA-N
Molecular Weight: 175.14
Canonical SMILES: COC(=O)CNC(=O)C(=O)OC
Isomeric SMILES: N/A
Molecular Formula: C6H9NO5

Compound Supplier

Supplier Name: Toronto Research Chemicals
Catalog #: D476325
Lot #: 5-RUS-16-1

Compound Characterization

HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C6H9NO5 176.05535; found 176.05545

Dose Response Curve

Platform ID: DMOG
Min: -17.0009; Max: 8.0792

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 05
Dose: 100µM
Days of incubation: 8
Doublings: 5.8
Numbers of reads: 15365092

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
15/17	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
ABCC4	-4.25	<0.01
ZBTB10	-3.58	<0.01
EGLN1	-3.32	<0.01
EIF3H	-3.14	<0.01
DERL2	-3.12	<0.01
LYL1	-2.97	<0.01
GCLC	-2.91	0.01
RBM15	-2.90	<0.01
TCF4	-2.79	<0.01
RSRC2	-2.72	0.19
SCAF8	-2.69	0.01
GCLM	-2.46	0.04
RNMT	-2.45	0.04
IREB2	-2.45	0.04
CDKN2B	-2.42	0.04
ALG9	-2.41	0.04
SPTY2D1	-2.31	0.07
STT3A	-2.28	0.21
USP17L19	-2.27	0.42
ZMYM2	-2.26	0.09
MC2R	-2.26	0.09
GMPPB	-2.25	0.30
CCDC101	-2.21	0.19
KIAA1432	-2.18	0.13
VPS25	-2.16	0.47
MOCS3	-2.14	0.21
DNAJB11	-2.13	0.16
NPTN	-2.12	0.17
MAP2K5	-2.10	0.18
SHOC2	-2.08	0.24
UCHL5	2.25	0.07
ZC3HAV1	2.28	0.06
TFDP1	2.28	0.16
RBM38	2.30	0.05
UCN3	2.31	0.05
RING1	2.31	0.09
MEMO1	2.32	0.05
NFRKB	2.33	0.05
PCGF1	2.35	0.05
ACLY	2.39	0.07
SPC24	2.44	0.47
GTF2A1	2.46	0.05
MAEA	2.48	0.02
TSC1	2.49	0.02
NDUFS2	2.52	0.07
HMG20A	2.55	0.02
ME2	2.61	0.02
PHF14	2.70	<0.01
CLPP	2.90	<0.01
OTUB1	2.99	<0.01
TMEM30A	3.15	<0.01
YPEL5	3.16	<0.01
UBE2H	3.23	<0.01
SCAP	3.29	<0.01
FBXL5	3.50	<0.01
SNX27	3.55	<0.01
ARNT	6.65	<0.01
HIF1A	6.72	<0.01
SLC16A7	6.82	<0.01
NIT2	7.77	<0.01

Last modified: 2026/01/15 21:36
by 127.0.0.1