STT3A
Gene Information
- Official Symbol: STT3A
- Official Name: STT3 oligosaccharyltransferase complex catalytic subunit A
- Aliases and Previous Symbols: N/A
- Entrez ID: 3703
- UniProt: P46977
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
- UniProt Summary: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post- translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. {ECO:0000250|UniProtKB:F1PJP5, ECO:0000269|PubMed:19167329, ECO:0000305}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13100
- Expression level (log2 read counts): 8.57
STT3A Expression in NALM6 Cells: 8.57
