FTY720 3μM R08 exp483

Agonist of sphingosine 1-phosphate receptor-1 (S1P1), derived from myriocin

PubChem Name: Fingolimod hydrochloride
Synonyms: FTY720
CAS #: 162359-56-0
PubChem CID: 107969
IUPAC: 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;hydrochloride
INCHI Name: InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
INCHI Key: SWZTYAVBMYWFGS-UHFFFAOYSA-N
Molecular Weight: 343.9
Canonical SMILES: CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
Isomeric SMILES: N/A
Molecular Formula: TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL

Characterization data not available.

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
17/1	Scores	View	View	View	View	View

Screen	Correlation	Plot
NN-Dimethylsphingosine 2.5μM R08 exp508	0.107	View
Thioridazine 5μM R08 exp530	0.098	View
Ibrutinib 10μM R08 exp442	0.091	View
Hydroxychloroquine 30μM R08 exp490	0.082	View
Wiskostatin 3μM R07 exp422	0.08	View
Nicotine 3000μM R08 exp510	0.066	View
UNC1999 2μM R03 exp155	0.059	View
Q15 1 to 2μM on day4 R04 exp164	0.059	View
LJH685 50μM R08 exp433	0.058	View
SGC0946 7μM R03 exp151	0.057	View
Vemurafenib 6.6μM R02 exp89	0.056	View
Prochlorperazine 5.2μM R02 exp77	0.056	View
MK2206 4μM R08 exp504	0.055	View
IU1-47 25μM R04 exp182	0.052	View
SB203580 25μM R03 exp149	0.052	View
Q15 2.7μM R02 exp79	0.051	View
Chlorpromazine 10μM R07 exp344	0.121	View
Chloroquine 32μM R08 exp470	0.093	View
Bafilomycin-A1 0.009μM R08 exp454	0.083	View
BS-181 20μM R08 exp461	0.079	View
Azithromycin 100μM R08 exp452	0.077	View
B02 10μM R08 exp453	0.077	View
Bisphenol F 50μM R08 exp457	0.076	View
Clomiphene 4.4μM R02 exp68	0.075	View
EPZ-5676 30μM R05 exp233	0.074	View
A-395 10μM R05 exp218	0.052	View
∆-9-Tetrahydrocannabinol 30μM R08 exp445	0.052	View
Cryptotanshinone 12μM R05 exp227	0.051	View
Cannabidiol 20μM R08 exp466	0.051	View

GO Term	Fold Change	Genes
fatty-acyl-CoA biosynthetic process	71.01	HSD17B12,SLC25A1,ACSL4
lipid biosynthetic process	10.33	CHKA,HSD17B12,FDPS,SCD,FDFT1,SLC25A1,AGPAT2,CERS2,ACSL4,PCYT1A
organophosphate biosynthetic process	9.17	CHKA,HSD17B12,FDPS,SLC25A1,AGPAT2,ADSL,ACSL4,PCYT1A
cellular lipid metabolic process	6.71	CHKA,HSD17B12,FDPS,SCD,DPAGT1,FDFT1,AGPAT2,CERS2,ACSL4,PCYT1A
organophosphate metabolic process	6.19	CHKA,HSD17B12,FDPS,FDFT1,SLC25A1,AGPAT2,ADSL,ACSL4,PCYT1A