FDFT1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Azithromycin 100μM R08 exp452	-3.58
Calcium Ionophore 0.4μM R07 exp342	-2.85
Lead acetate 2000μM R08 exp498 no dilution day6	-2.73
FTY720 3μM R08 exp483	-2.69
Lead acetate 2000μM R08 exp497	-2.63
UNC1999 2μM R03 exp155	-2.47
SGC0946 7μM R03 exp151	-2.25
GSK343 3μM R03 exp124	-2.16
Thapsigargin 0.005μM R07 exp407	-2.13
Tubastatin-A 2.5μM R07 exp417	-2.09
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.06
CB-839 10μM R05 exp224	-2.01
L-74142 5μM R03 exp131	-1.82
EPZ-5676 30μM R05 exp233	-1.78
Fluvastatin 2.2μM R06 exp282	3.53
Cerivastatin 0.15μM R05 exp226	3.81

Global Fraction of Cell Lines Where Essential: 9/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	2/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

squalene synthase activity
farnesyl-diphosphate farnesyltransferase activity
ergosterol biosynthetic process
ergosterol metabolic process
phytosteroid metabolic process
phytosteroid biosynthetic process
farnesyl diphosphate metabolic process
cellular alcohol biosynthetic process
cellular alcohol metabolic process
cellular lipid biosynthetic process
cholesterol biosynthetic process
secondary alcohol biosynthetic process
regulation of cholesterol biosynthetic process
regulation of sterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
terpenoid metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
steroid metabolic process
alcohol metabolic process
phospholipid metabolic process
regulation of lipid metabolic process
regulation of small molecule metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
small molecule biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum