FDFT1 [The Human Chemical-Genetic Interaction Map Project]

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======= FDFT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FDFT1
  * **<color #00a2e8>Official Name</color>**: farnesyl-diphosphate farnesyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2222|2222]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P37268|P37268]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FDFT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FDFT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/184420|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SQS PSY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|squalene synthase activity|
|farnesyl-diphosphate farnesyltransferase activity|
|ergosterol biosynthetic process|
|ergosterol metabolic process|
|phytosteroid metabolic process|
|phytosteroid biosynthetic process|
|farnesyl diphosphate metabolic process|
|cellular alcohol biosynthetic process|
|cellular alcohol metabolic process|
|cellular lipid biosynthetic process|
|cholesterol biosynthetic process|
|secondary alcohol biosynthetic process|
|regulation of cholesterol biosynthetic process|
|regulation of sterol biosynthetic process|
|sterol biosynthetic process|
|regulation of cholesterol metabolic process|
|regulation of alcohol biosynthetic process|
|regulation of steroid biosynthetic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|cholesterol metabolic process|
|terpenoid metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|isoprenoid metabolic process|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|steroid metabolic process|
|alcohol metabolic process|
|phospholipid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|organic hydroxy compound metabolic process|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-3.58|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.85|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.73|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.69|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.63|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-2.47|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-2.25|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-2.16|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.13|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.09|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.06|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.01|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.82|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.78|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|3.53|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8646
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FDFT1 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>