AGPAT2

Gene Information

Official Symbol: AGPAT2
Official Name: 1-acylglycerol-3-phosphate O-acyltransferase 2
Aliases and Previous Symbols: N/A
Entrez ID: 10555
UniProt: O15120
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UniProt Summary: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:15629135, ECO:0000269|PubMed:21873652, ECO:0000269|PubMed:9242711}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.8
FTY720 3μM R08 exp483	-2.56
UM0130462 0.025 to 0.035μM day4 R05 exp247	-2.25
Cisplatin 0.35μM R06 exp273	-1.96
TRAIL 5ng/ml R00 exp35	-1.85
CB-839 10μM R05 exp224	-1.71
5-Fluorouracil 2μM R00 exp1	-1.7
Hydroxyurea 100μM R07 exp329	1.72
Staurosporine 0.02μM R08 exp524	1.72
UNC2400 2μM R03 exp156	1.81
MK2206 4μM R08 exp504	1.88
QNZ 0.01μM R08 exp439	2.12
Palbociclib 1μM R07 exp382	2.17
Fluvastatin 2.2μM R06 exp282	2.46

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12070
Expression level (log2 read counts): 3.48

Expression Distribution

CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
1-acylglycerol-3-phosphate O-acyltransferase activity
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
pyrimidine nucleotide biosynthetic process
positive regulation of cytokine-mediated signaling pathway
pyrimidine-containing compound biosynthetic process
positive regulation of response to cytokine stimulus
pyrimidine nucleotide metabolic process
specific granule membrane
pyrimidine-containing compound metabolic process
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
epidermis development
nucleotide metabolic process
positive regulation of cytokine production
nucleoside phosphate metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response