Palbociclib 1μM R07 exp382

Mechanism of Action

Inhibits CDK4 and CDK6, causes G1 arrest

  • Class / Subclass 1: Cell Cycle / Cyclin Dependent Kinase Inhibitor
  • Class / Subclass 2: Signal Transduction / Kinase Inhibitor

Technical Notes

Compound References

  • PubChem Name: Palbociclib
  • Synonyms: PD 0332991
  • CAS #: 571190-30-2
  • PubChem CID: 5330286
  • IUPAC: 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
  • INCHI Name: InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
  • INCHI Key: AHJRHEGDXFFMBM-UHFFFAOYSA-N
  • Molecular Weight: 447.5
  • Canonical SMILES: CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C
  • Isomeric SMILES: N/A
  • Molecular Formula: C24H29N7O2

Compound Supplier

  • Supplier Name: Ark Pharm Inc.
  • Catalog #: AK173631
  • Lot #: WG0167187-160912001

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C24H29N7O2 448.24555; found 448.24521

Dose Response Curve

  • Platform ID: Palbociclib
  • Min: 12.7342; Max: 53.0111





IC Concentration (µM)
IC10 N/A
IC20 0.0476
IC30 0.3364
IC40 1.7300
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 07
  • Dose: 1µM
  • Days of incubation: 8
  • Doublings: 0.6
  • Numbers of reads: 16273129

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
12/5ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1